Principal Bioprocess Automation Architect Upstream/Downstream

Amgen Inc. (IR); Holly Springs (NC); On-site; USD 140,000 - 190,000; Full time

Job summary

Amgen Inc. is seeking a Principal Manufacturing Systems Engineer for Upstream/Downstream Process Automation at its FleX Batch facility in North Carolina.

This role leads automation design, commissioning, and qualification to support 24/7 drug substance production, collaborating across Engineering, Manufacturing, and Quality teams to ensure robust, compliant automation solutions. Qualifications include advanced engineering education and 2+ years of managerial experience, with extensive DeltaV

Qualifications

• Doctorate/Master/Bachelor/Associate/HS diploma with progressively increased engineering experience are accepted as Basic Qualifications.
• Must have 2 years of managerial experience directly managing people and/or leadership experience leading teams, projects, programs or directing resources.
• Degree in Electrical Engineering, Computer Science, Chemical Engineering or Biotech Engineering is preferred.

Responsibilities

• Site design, construction, start-up, and operational readiness; participate in design reviews.
• Lead commissioning and qualification of process equipment automation per GMP.
• Ensure operational capability aligns with GMP and project timelines.
• Collaborate with site process engineering to develop automation solutions using DeltaV DCS.
• Provide mentoring to develop site automation capabilities.
• Support 24/7 operations with on-site/on-call automation support and issue resolution.

Skills

Team leadership

Mentoring

Problem solving

Communication

Education

Electrical Engineering

Biotech Engineering

Tools

Emerson DeltaV

OPC

IO-Link

Job description

Amgen Inc. is seeking a Principal Manufacturing Systems Engineer for Upstream/Downstream Process Automation at its FleX Batch facility in North Carolina.

This role leads automation design, commissioning, and qualification to support 24/7 drug substance production, collaborating across Engineering, Manufacturing, and Quality teams to ensure robust, compliant automation solutions. Qualifications include advanced engineering education and 2+ years of managerial experience, with extensive DeltaV