Principal Manufacturing Automation Engineer Up/Downstream

BioSpace; Holly Springs (NC); On-site; USD 150,000 - 190,000; Full time

Job summary

Amgen is seeking a Principal Manufacturing Systems Engineer to lead automation for upstream and downstream bioprocessing at the FleXBatch facility. You will drive design, build, commissioning, and qualification of automation systems and partner with global teams to ensure readiness for 24/7 operations.

The role emphasizes mentorship, regulatory compliance, and continuous improvement, with travel up to 10% and strong leadership in a modern biopharma setting.

Qualifications

• Degrees in engineering with multiple experience levels as listed in the ad.
• Experience with GMP and regulated manufacturing environments.
• Experience leading automation projects and cross-functional teams.

Responsibilities

• Lead automation design, commissioning, and qualification for upstream and downstream bioprocessing.
• Provide 24/7 operations support and on-call troubleshooting.
• Collaborate across Engineering, Manufacturing, and Quality teams to ensure compliant, scalable automation solutions.
• Mentor junior engineers and drive continuous improvement in safety, reliability, and efficiency.

Skills

DeltaV

GMP

Automation

Leadership

Process control

Education

Bachelor's degree in Engineering

Master's degree in Engineering

Doctorate degree in Engineering

Associates degree in Engineering

Tools

Emerson DeltaV

Job description

Amgen is seeking a Principal Manufacturing Systems Engineer to lead automation for upstream and downstream bioprocessing at the FleXBatch facility. You will drive design, build, commissioning, and qualification of automation systems and partner with global teams to ensure readiness for 24/7 operations.

The role emphasizes mentorship, regulatory compliance, and continuous improvement, with travel up to 10% and strong leadership in a modern biopharma setting.