Postdoctoral Scientist: CRISPR Mouse Models & dTAG

Baylor College of Medicine (BCM); Houston (TX); On-site; USD 52,000 - 72,000; Full time

Job summary

The Center for Drug Discovery at Baylor College of Medicine in Houston seeks a Postdoctoral Research Associate to develop dTAG-KI mouse models for NIH-funded research. You will use CRISPR/Cas9 genome editing, molecular biology, and in vivo experiments to study drug-metabolizing enzyme regulation and function.

The role offers advanced training in genome engineering and translational pharmacology. Applicants should have MD or PhD and may qualify with strong molecular biology and mouse-model

Qualifications

• MD or Ph.D. in Basic Science, Health Science, or a related field.
• No experience required for minimum qualifications.
• Preferred: PhD, MD, or equivalent in molecular biology, genetics, pharmacology, or related discipline.
• Experience with mouse breeding and colony management is a plus.

Responsibilities

• Collaborates with Genetically Engineered Rodent Models Core to design CRISPR/Cas9 strategies for dTAG-KI mouse models.
• Collects blood, tissues, and samples at designated time points.
• Evaluates target-protein expression and degradation via Western blotting.
• Performs animal dosing and experimental treatments through appropriate routes.
• Maintains mouse colony management including breeding and recordkeeping.
• Conducts pharmacological and DMPK studies and analyzes data.
• Prepares figures, reports, manuscripts, and presentations.

Skills

CRISPR/Cas9 genome editing

Molecular biology

Animal handling

Data analysis

Scientific communication

Education

MD or Ph.D. in Basic Science or related field

PhD/MD or equivalent in molecular biology/genetics/pharmacology

Tools

Western blotting

CRISPR/Cas9 tools

Genetically engineered mouse models

Job description

The Center for Drug Discovery at Baylor College of Medicine in Houston seeks a Postdoctoral Research Associate to develop dTAG-KI mouse models for NIH-funded research. You will use CRISPR/Cas9 genome editing, molecular biology, and in vivo experiments to study drug-metabolizing enzyme regulation and function.

The role offers advanced training in genome engineering and translational pharmacology. Applicants should have MD or PhD and may qualify with strong molecular biology and mouse-model