Postdoc: CRISPR & dTAG Mice for Drug Discovery

Baylor College of Medicine (BCM); Houston (TX); On-site; USD 52,000 - 68,000; Full time

Job summary

The Center for Drug Discovery at Baylor College of Medicine in Houston seeks a Postdoctoral Research Associate to develop and characterize dTAG-KI mouse models for biomedical research. The role employs CRISPR/Cas9, molecular biology, and in vivo experiments to study drug-metabolizing enzymes in vivo, enabling on/off control with dTAG molecules.

NIH R01-funded project; BCM provides NIH-style stipend guidance.

Qualifications

• MD or PhD in basic science, health science, or related field.
• No experience required.
• Experience with mouse breeding and colony management.
• Proficiency in molecular biology techniques, especially Western blotting.
• Experience with CRISPR/Cas9 genome editing or genetically engineered mouse models.
• Familiarity with inducible protein-degradation systems including dTAG technology.
• Evidence of scientific productivity through publications or presentations.
• Ability to work independently and in a multidisciplinary setting.

Responsibilities

• Collaborates with Genetically Engineered Rodent Models Core to design and optimize CRISPR/Cas9 strategies for dTAG-KI mouse models.
• Collects blood, tissues, and other samples at designated time points.
• Evaluates target-protein expression and degradation using Western blotting and related methods.
• Performs animal dosing and experimental treatments via appropriate routes.
• Manages mouse colonies including breeding, weaning, and recordkeeping.
• Conducts molecular characterization and pharmacological studies (DMPK).
• Analyzes data, keeps accurate records, and prepares figures, reports, manuscripts, and presentations.
• Performs other job-related duties as assigned.

Skills

CRISPR/Cas9 genome editing

Molecular biology

Western blotting

Genetically engineered mouse models

Inducible protein degradation (dTAG)

Data analysis

Scientific communication

Independent and collaborative work

Education

MD or PhD in Basic/Health Science or related field

Equivalent doctoral degree (MD/PhD)

Tools

Western blotting

Job description

The Center for Drug Discovery at Baylor College of Medicine in Houston seeks a Postdoctoral Research Associate to develop and characterize dTAG-KI mouse models for biomedical research. The role employs CRISPR/Cas9, molecular biology, and in vivo experiments to study drug-metabolizing enzymes in vivo, enabling on/off control with dTAG molecules.

NIH R01-funded project; BCM provides NIH-style stipend guidance.