Postdoctoral Fellow — Structural Biology & Biosynthetic Enzymology

University at Buffalo; Buffalo (NY); Hybrid; USD 55,000 - 65,000; Full time

Job summary

University at Buffalo invites applications for a Postdoctoral Research Associate in the Gulick Lab within the Department of Structural Biology. The NIH-funded role focuses on protein production, purification, and structural biology to explore bacterial natural product biosynthesis.

The successful candidate will perform biochemical assays, genome mining, and single-particle structure determination, with opportunities for co-authored publications. Downtown Campus, NY, 37.5 hours/week.

Qualifications

• PhD in Biochemistry, Chemistry, or related field.
• Background in protein biochemistry, enzymology, biophysical analysis, or structural biology.
• Ability to analyze, publish, and present research data.
• Self-motivation, ability to work both independently and collaboratively as a team.

Responsibilities

• protein production, purification, and analysis, including development and implementation of biochemical assays
• informatic and genome mining to identify, characterize, and understand the diverse biosynthetic pathways of bacterial sources
• protein structure determination through X-ray crystallography and/or cryo-electron microscopy and single particle analysis
• Data analysis, maintenance, and interpretation, including contributions on authoring publications and dissemination of research

Skills

Protein production

Purification

Biochemical assays

Genome mining

X-ray crystallography

Cryo-EM

Data analysis

Publications

Collaborative

Self-motivation

Education

PhD in Biochemistry

PhD in Chemistry

Job description

A Postdoctoral Research Associate position is available for an NIH -funded position in the lab of Prof. Andrew Gulick within the Department of Structural Biology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo.

The Gulick Lab investigates the structural enzymology of proteins involved in the biosynthesis of bacterial natural products. Through combinations of structural biology, biochemical characterization, protein engineering, and biocatalysis, we aim to explore the ability of bacteria to produce diverse small molecules that are produced to help them adapt to the challenges of surviving in diverse environments.

The postdoctoral associate will be responsible for:

• protein production, purification, and analysis, including development and implementation of biochemical assays
• informatic and genome mining to identify, characterize, and understand the diverse biosynthetic pathways of bacterial sources
• protein structure determination through X-ray crystallography and/or cryo-electron microscopy and single particle analysis
• Data analysis, maintenance, and interpretation, including contributions on authoring publications and dissemination of research

Learn more:

• Our benefits , where we prioritize your well-being and success to enhance every aspect of your life.

The Research Foundation of SUNY is an EOE and welcomes all to apply including veterans and individuals with a disability.

Minimum Qualifications

• PhD in Biochemistry, Chemistry, or related field
• Background in protein biochemistry, enzymology, biophysical analysis, or structural biology
• Ability to analyze, publish, and present research data
• Self-motivation, ability to work both independently and collaboratively as a team. Ability to manage time and organization on multiple projects

Preferred Qualifications

• Interest in natural product biosynthesis, including pathway reconstitution, genetic manipulation, small molecule isolation and characterization
• Expertise in enzymology, including assay development, LC-MS and HPLC analysis
• Experience with X-ray crystallographic analysis and protein structure determination or single particle cryo-electron microscopy structure determination and analysis
• Familiarity with computation tools for protein structure determination and analysis.

Our University Community

Physical Demands

Driving Requirements

Driving Requirements This position will never drive a university owned vehicle.

Salary Range

Salary Range $55,000 - $65,000

Additional Salary Information

Additional Salary Information The salary range reflects our good faith and reasonable estimate of the possible compensation at the time of posting, the role and associated responsibilities, and the experience, education, and training of the selected candidate.

Work Hours

37.5 hours per week

Campus

Campus Downtown Campus

Posting Alerts

Special Instructions Summary

Is a background check required for this posting?

Is a background check required for this posting? No

Contact Information

Contact's Name

Contact's Pronouns

Contact's Title

Contact's Title Professor

Contact's Email

Contact's Phone

Contact's Phone [phone]

Posting Dates

Posted

Posted 09/25/2026

Date to be filled

References

Number of references required

Number of references required 3

Reference Cutoff Date

Instructions to Applicant

Supplemental Questions

Required fields are indicated with an asterisk (*).

• * Please indicate your current employment affiliation with the University at Buffalo.
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  • State Professional
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  • No Current Employment Affiliation
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UB is an AA/EOE and welcomes all to apply including veterans and individuals with disabilities. Arrangements will be made if an applicant has a disability in order to provide access to the application, interview and selection process upon request. Reasonable accommodation requests must be made in a timely manner by email at [e-mail] or by phone [phone].