Postdoctoral Fellow - Genomic Medicine

MD Anderson Cancer Center; Houston (TX); On-site; USD 55,000 - 75,000; Full time

Job summary

A leading cancer research institution in Houston is seeking motivated Postdoctoral Fellows to explore tumor cell heterogeneity and evolution using advanced bioinformatics approaches. Candidates should have a PhD in computational biology, bioinformatics, or related fields, and strong computational skills including proficiency in R and Python. The role involves analyzing complex data, contributing to publications, and developing expertise in study design and data interpretation. This position offers a unique chance to advance cancer research and improve patient care.

Qualifications

• PhD degree in computational biology, bioinformatics, data science, or a related field.
• Strong computational skills and experience in R and one additional scripting language.
• Preferred experience in single cell and spatial omics data analysis.

Responsibilities

• Analyze single cell and spatial omics data to understand tumor evolution.
• Apply bioinformatics tools to dissect the tumor ecosystem.
• Contribute to research publications and grant writing.

Skills

Strong computational background

Proficiency in R

Experience with Python

Knowledge in biostatistics

Experience with single cell and spatial omics

High-performance computing (Unix/Linux)

Understanding of cancer biology

Excellent communication skills

Education

PhD in computational biology, bioinformatics, data science or a related field

Job description

The Wang Laboratory at MD Anderson Cancer Center is a computational biology research lab. We apply innovative bioinformatics approaches to dissect the tumor 'ecosystem', deeply profile tumor cells and cells of the tumor microenvironment as well as tumor‑immune‑stroma crosstalk at single‑cell resolution and in the spatial context. The lab's key focus areas include:

• Transition from premalignant lesions to invasive cancer
• Evolution of metastasis from a localized tumor
• Dynamic response to anti‑cancer therapies and the development of therapeutic resistance

Leveraging cutting‑edge single‑cell and spatial multi‑omics technologies, cellular imaging, and innovative bioinformatics tools and computational frameworks, we aim to harness the potential of big data to fight cancer. Our overarching goal is to advance our understanding of the cellular & molecular cues underlying early tumorigenesis, disease progression, and the development of therapy resistance and translate our novel discoveries into improved patient care. We are seeking multiple talented and highly motivated Postdoctoral Fellows with a strong background in bioinformatics and a passion for exploring the heterogeneity and evolution of tumor cells and tumor microenvironment using the state‑of‑the‑art single cell and spatial multi‑omics approaches.

Learning Objectives

• Gain skills in single cell, spatial omics, and imaging data analysis, immunogenomics, immune‑informatics, and cancer‑specific bioinformatics.
• Develop expertise in study design, data analysis, data interpretation, presentation, manuscript and grant writing.

Eligibility Requirements

Individuals with a PhD degree in computational biology, bioinformatics, data science or a related field are encouraged to apply. A strong computational background, proficiency in R and at least one additional scripting language (e.g., Python) and knowledge in biostatistics are required. Experience working with single cell and spatial omics data analysis and high‑performance computing environment (Unix/Linux) is highly preferred. A good understanding of cancer biology, immunology, cell biology, and molecular biology is also preferred. Proven track record of publications, excellent spoken and written communication skills are required.

Additional Application Information

Interested applicants should send a Cover Letter specifying past research experience/skills/accomplishments, a Curriculum Vitae and the contact information of three (3) Referees to Dr. Linghua Wang at [e-mail] with the subject line entitled "Postdoctoral Fellow – Application – Applicant’s Name".

Position Information

Offsite work arrangements are subject to approval and may be modified or revoked at any time based on business needs, performance considerations, or regulatory requirements. This position may be responsible for maintaining the security and integrity of critical infrastructure, as defined in Section 113.001(2) of the Texas Business and Commerce Code and therefore may require routine reviews and screening. The ability to satisfy and maintain all requirements necessary to ensure the continued security and integrity of such infrastructure is a condition of hire and continued employment.

It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law.

Faculty Mentor

Dr. Linghua Wang