Postdoctoral Fellow - Cardiac Bioengineering & Maturation

Mount Sinai; New York (NY); On-site; USD 73,000 - 80,000; Full time

Benefits offered by this job

Ambitious program

AVCC network integration

State-of-the-art facilities

Interdisciplinary environment

Mentorship program

Competitive compensation

Job summary

The Dubois Laboratory at Mount Sinai Health System in New York invites applications for a highly motivated Postdoctoral Fellow to lead a research program focused on generating mature cardiomyocytes from hiPSCs and applying them to a pulsatile cardiac conduit as a potential therapy for single ventricle disease. The project spans stem cell biology, cardiac differentiation, tissue engineering, and physiology.

This position offers integration into the AVCC network, access to state‑of‑the‑art

Qualifications

• PhD/MD-PhD or equivalent required in cell/developmental biology, biomed eng, physiology or related field.
• Experience with human pluripotent stem cell culture and directed cardiac differentiation.
• Strong publication record and evidence of independent thinking.
• Solid foundation in cell/molecular biology techniques.
• Excellent written and oral communication; able to present in scientific forums.
• Ability to work independently and collaboratively in a multidisciplinary environment.
• Enthusiasm for translational research and clinical problem of single ventricle disease.

Responsibilities

• Lead design and execution of projects generating mature hiPSC-derived cardiomyocytes for therapeutic applications in single ventricle disease.
• Develop and optimize maturation protocols including metabolic, electrical, mechanical, and structural endpoints.
• Collaborate with AVCC partners on integrating mature cardiomyocytes into pulsatile conduit constructs.
• Apply functional assays (electrophysiology, calcium imaging, contractility, metabolism) to characterize maturity.
• Use single-cell and spatial transcriptomics to interrogate cardiomyocyte identity and heterogeneity.
• Mentor junior lab members and contribute to cross-institutional data sharing.
• Contribute to preparation and dissemination of research findings.

Skills

Stem cell culture

Cardiac differentiation

Publications

Molecular biology

Communication

Independent work

Translational research

Education

PhD in related field

Job description

The Dubois Laboratory at Mount Sinai Health System in New York invites applications for a highly motivated Postdoctoral Fellow to lead a research program focused on generating mature cardiomyocytes from hiPSCs and applying them to a pulsatile cardiac conduit as a potential therapy for single ventricle disease. The project spans stem cell biology, cardiac differentiation, tissue engineering, and physiology.

This position offers integration into the AVCC network, access to state‑of‑the‑art