Postdoctoral Fellow-MSH-30020-176

Mount Sinai; United States; On-site; USD 70,000 - 110,000; Full time

Job summary

Mount Sinai's Dubois Laboratory seeks a highly motivated Postdoctoral Fellow to lead a program generating mature hiPSC-derived cardiomyocytes for a pulsatile conduit therapy for single ventricle disease. This scientifically ambitious project spans stem cell biology, cardiac differentiation, tissue engineering, and functional physiology.

You will collaborate with AVCC partners, contribute to data sharing, and mentor junior researchers while advancing translational research toward clinical impact.

Qualifications

• PhD, MD/PhD, or equivalent doctoral degree in cell biology, developmental biology, biomedical engineering, physiology, or a closely related field.
• Demonstrated expertise in human pluripotent stem cell culture and directed cardiac differentiation.
• Strong publication record commensurate with experience, with evidence of independent scientific thinking and productivity.
• Solid foundation in cell and molecular biology techniques.
• Excellent written and oral communication skills, including experience presenting in scientific forums.
• Ability to work independently and collaboratively in a multidisciplinary research environment.
• Enthusiasm for translational research.

Responsibilities

• Lead the design and execution of research projects aimed at generating highly functional and mature cardiomyocytes from human pluripotent stem cells (hiPSCs) for therapeutic applications in single ventricle disease.
• Develop and optimize protocols for cardiomyocyte maturation, including metabolic, electrical, mechanical, and structural maturation endpoints.
• Collaborate with AVCC bioengineering partners on the integration of mature cardiomyocytes into pulsatile conduit constructs, contributing biological expertise to an interdisciplinary design process.
• Apply advanced functional assays to characterize cardiomyocyte maturity and performance, including electrophysiology, calcium imaging, contractile force measurements, and metabolic profiling.
• Leverage single-cell and spatial transcriptomic tools to interrogate cardiomyocyte identity, maturation state, and functional heterogeneity.
• Participate actively in AVCC collaborative meetings, contribute to cross-institutional data sharing, and help build the broader single ventricle research community.
• Mentor junior laboratory members including graduate students and research technicians.
• Contribute to the preparation

Skills

HiPSC culture

Cardiac differentiation

Independent researcher

Collaborative teamwork

Education

PhD/MD-PhD or equivalent

Tools

Electrophysiology

Calcium imaging

Single-cell transcriptomics

Spatial transcriptomics

Job description

In response to this challenge, Additional Ventures - a nonprofit organization dedicated to funding transformative research in single ventricle heart disease - has established the Additional Ventures Cures Collaborative (AVCC), an ambitious, multi-institutional, and deeply interdisciplinary consortium with the explicit goal of developing curative therapies for patient living with single ventricle disease. https://www.additionalventures.org/initiatives/biomedical-research/cures-collaborative/ The AVCC brings together leading investigators across cardiac developmental biology, bioengineering, regenerative medicine, stem cell biology, computational modeling, and clinical cardiology, creating a uniquely integrated research environment that bridges the full spectrum from fundamental science to translational application. The Dubois Laboratory is a proud member of this collaborative, embedded within a rapidly expanding and highly connected community of single ventricle researchers who share data, tools, and insights across institutional boundaries. This position offers an exceptional opportunity to conduct research at the heart of this effort, with direct access to the collaborative's scientific network, resources, and translational momentum.

About the Dubois Laboratory

The Dubois Laboratory investigates the fundamental mechanisms governing cardiac development, with particular focus on ventricular chamber morphogenesis, cardiomyocyte specification and maturation, and the developmental origins of congenital heart disease. We combine mouse genetics, human pluripotent stem cell models, single-cell and spatial transcriptomics, and functional assays to understand how the heart is built and how that process is compromised in disease. Our work is deeply integrated with the AVCC's mission, and the successful candidate will work at the intersection of developmental biology, stem cell science, and cardiac bioengineering to advance a transformative therapeutic strategy for single ventricle disease. https://labs.icahn.mssm.edu/duboislab/

Position Overview

The Dubois Laboratory is recruiting a highly motivated Postdoctoral Fellow to lead a research program focused on the generation of highly functional, mature cardiomyocytes and their application toward building a pulsatile cardiac conduit as a potential therapy for single ventricle heart disease. This is a scientifically ambitious and technically multidisciplinary project that will require expertise spanning stem cell biology, cardiac differentiation, tissue engineering, and functional cardiac physiology. The successful candidate will have a central and intellectually independent role in shaping and executing this research, working in close collaboration with AVCC partners across institutions and disciplines. We are looking for an individual who combines scientific rigor and creativity with the drive to work both independently and as a fully engaged member of a collaborative team. This position is ideally suited to a researcher who is motivated by the prospect of developing work that could ultimately benefit patients.

Key Responsibilities

• Lead the design and execution of research projects aimed at generating highly functional and mature cardiomyocytes from human pluripotent stem cells (hiPSCs) for therapeutic applications in single ventricle disease
• Develop and optimize protocols for cardiomyocyte maturation, including metabolic, electrical, mechanical, and structural maturation endpoints
• Collaborate with AVCC bioengineering partners on the integration of mature cardiomyocytes into pulsatile conduit constructs, contributing biological expertise to an interdisciplinary design process
• Apply advanced functional assays to characterize cardiomyocyte maturity and performance, including electrophysiology, calcium imaging, contractile force measurements, and metabolic profiling
• Leverage single-cell and spatial transcriptomic tools to interrogate cardiomyocyte identity, maturation state, and functional heterogeneity
• Participate actively in AVCC collaborative meetings, contribute to cross-institutional data sharing, and help build the broader single ventricle research community
• Mentor junior laboratory members including graduate students and research technicians
• Contribute to the preparation

Qualifications

Required

• PhD, MD/PhD, or equivalent doctoral degree in cell biology, developmental biology, biomedical engineering, physiology, or a closely related field
• Demonstrated expertise in human pluripotent stem cell culture and directed cardiac differentiation
• Strong publication record commensurate with experience, with evidence of independent scientific thinking and productivity
• Solid foundation in cell and molecular biology techniques
• Excellent written and oral communication skills, including experience presenting in scientific forums
• Ability to work independently and collaboratively in a multidisciplinary research environment
• Enthusiasm for translational re