Postdoc: Cardiac Bioengineering for Pulsatile Therapies

Mount Sinai; United States; On-site; USD 70,000 - 110,000; Full time

Job summary

Mount Sinai's Dubois Laboratory seeks a highly motivated Postdoctoral Fellow to lead a program generating mature hiPSC-derived cardiomyocytes for a pulsatile conduit therapy for single ventricle disease. This scientifically ambitious project spans stem cell biology, cardiac differentiation, tissue engineering, and functional physiology.

You will collaborate with AVCC partners, contribute to data sharing, and mentor junior researchers while advancing translational research toward clinical impact.

Qualifications

• PhD, MD/PhD, or equivalent doctoral degree in cell biology, developmental biology, biomedical engineering, physiology, or a closely related field.
• Demonstrated expertise in human pluripotent stem cell culture and directed cardiac differentiation.
• Strong publication record commensurate with experience, with evidence of independent scientific thinking and productivity.
• Solid foundation in cell and molecular biology techniques.
• Excellent written and oral communication skills, including experience presenting in scientific forums.
• Ability to work independently and collaboratively in a multidisciplinary research environment.
• Enthusiasm for translational research.

Responsibilities

• Lead the design and execution of research projects aimed at generating highly functional and mature cardiomyocytes from human pluripotent stem cells (hiPSCs) for therapeutic applications in single ventricle disease.
• Develop and optimize protocols for cardiomyocyte maturation, including metabolic, electrical, mechanical, and structural maturation endpoints.
• Collaborate with AVCC bioengineering partners on the integration of mature cardiomyocytes into pulsatile conduit constructs, contributing biological expertise to an interdisciplinary design process.
• Apply advanced functional assays to characterize cardiomyocyte maturity and performance, including electrophysiology, calcium imaging, contractile force measurements, and metabolic profiling.
• Leverage single-cell and spatial transcriptomic tools to interrogate cardiomyocyte identity, maturation state, and functional heterogeneity.
• Participate actively in AVCC collaborative meetings, contribute to cross-institutional data sharing, and help build the broader single ventricle research community.
• Mentor junior laboratory members including graduate students and research technicians.
• Contribute to the preparation

Skills

HiPSC culture

Cardiac differentiation

Independent researcher

Collaborative teamwork

Education

PhD/MD-PhD or equivalent

Tools

Electrophysiology

Calcium imaging

Single-cell transcriptomics

Spatial transcriptomics

Job description

Mount Sinai's Dubois Laboratory seeks a highly motivated Postdoctoral Fellow to lead a program generating mature hiPSC-derived cardiomyocytes for a pulsatile conduit therapy for single ventricle disease. This scientifically ambitious project spans stem cell biology, cardiac differentiation, tissue engineering, and functional physiology.

You will collaborate with AVCC partners, contribute to data sharing, and mentor junior researchers while advancing translational research toward clinical impact.