Postdoc: Synuclein Biology & Neurodegeneration

BioSpace; Boston (MA); On-site; USD 58,000 - 123,000; Full time

Job summary

Lilly’s Neurodegeneration Biology group in Boston seeks a Postdoctoral Scientist to investigate α‑synuclein dysfunction and aggregation in disease. The role blends protein biophysics, cell biology, and translational neuroscience to build a mechanistic basis for new therapies in synucleinopathy.

The position emphasizes engineered cell systems, iPSC‑derived neurons, and biochemical readouts, with opportunity for collaborative discovery and publications.

Qualifications

• PhD in cell biology, biochemistry, molecular biology, neuroscience, protein biophysics, or a related field.
• Hands‑on expertise in protein aggregation biochemistry, including ThT‑based kinetic assays.
• Experience generating and engineering mammalian cell lines, including approaches such as CRISPR editing, lentiviral transduction, or stable line development.
• Experience with recombinant protein expression, purification, and biochemical or biophysical characterization.
• Authorized to work in the United States on a full‑time basis; Lilly will not sponsor work authorization or visas for this role.

Responsibilities

• Design and execute experiments to define molecular and cellular mechanisms driving α‑synuclein aggregation and dysfunction.
• Develop cellular models, including engineered cell lines and iPSC‑derived neurons, for studying α‑synuclein biology.
• Perform Thioflavin T (ThT) fluorescence assays to quantify aggregation kinetics across conditions.
• Use imaging‑based approaches to characterize aggregation and cellular phenotypes.
• Collaborate with scientists across Lilly’s Boston site and external academic partners; present findings at meetings and publications.

Skills

Protein aggregation biochemistry

Mammalian cell line engineering

Recombinant protein expression & bioph

Education

PhD in cell biology/biochemistry/neuroscience

Job description

Lilly’s Neurodegeneration Biology group in Boston seeks a Postdoctoral Scientist to investigate α‑synuclein dysfunction and aggregation in disease. The role blends protein biophysics, cell biology, and translational neuroscience to build a mechanistic basis for new therapies in synucleinopathy.

The position emphasizes engineered cell systems, iPSC‑derived neurons, and biochemical readouts, with opportunity for collaborative discovery and publications.