Postdoctoral Scientist — Synuclein Neuroscience

Eli Lilly and Company; Boston (MA); On-site; USD 85,000 - 110,000; Full time

Job summary

Eli Lilly and Company in Boston is seeking a Postdoctoral Scientist to investigate α-synuclein biology and aggregation in disease. You will build cellular models and apply biochemical readouts in a collaborative drug discovery environment.

Ideal candidates have a PhD with hands-on aggregation biochemistry, cell line engineering, and a strong publication record. Fixed-term postdoc with potential for full-time opportunities.

Qualifications

• PhD in cell biology, biochemistry, molecular biology, neuroscience, protein biophysics, or a related field (or near graduation).
• Hands-on protein aggregation biochemistry experience, including ThT-based assays.
• Experience generating/engineering mammalian cell lines (CRISPR, LV, stable lines).
• Experience with recombinant protein expression and characterization.
• Authorized to work in the United States full-time.

Responsibilities

• Lead experiments to define molecular/cellular drivers of α-synuclein aggregation.
• Develop cellular models and iPSC-derived neurons for disease-relevant systems.
• Use seeded aggregation and recombinant fibril generation to study misfolding kinetics.
• Apply ThT and other readouts to quantify aggregation across conditions.
• Validate findings in neuronal models using imaging and biochemistry.
• Collaborate across Lilly Boston site and with external partners.
• Present findings at meetings and contribute to publications.
• Maintain rigorous documentation in ELB.

Skills

Aggregation biochemistry

Cell line engineering

Data analysis

Strong communication

Independent work

Education

PhD in a relevant field

Tools

CRISPR editing

Lentiviral transduction

Stable cell lines

Recombinant protein expression

Protein purification

Biochemical characterization

Biophysical characterization

Job description

Eli Lilly and Company in Boston is seeking a Postdoctoral Scientist to investigate α-synuclein biology and aggregation in disease. You will build cellular models and apply biochemical readouts in a collaborative drug discovery environment.

Ideal candidates have a PhD with hands-on aggregation biochemistry, cell line engineering, and a strong publication record. Fixed-term postdoc with potential for full-time opportunities.