Postdoc: Lysosomal Metabolism & Neuroprotection Research

Eli Lilly and Company; Boston (MA); On-site; USD 58,000 - 123,000; Full time

Benefits offered by this job

Company bonus

401(k) plan

Comprehensive benefits

Job summary

Eli Lilly and Company in Boston invites applications for a Postdoctoral Scientist in the Lilly Gene Therapy (LGT) organization. The role focuses on lysosomal biology and metabolic regulation using multi-omics across tissues, including CNS and peripheral sites.

You will lead LC-MS–based lipidomics, metabolomics, and proteomics studies, integrate transcriptomic data, and contribute to mechanistic understanding of lysosomal health in inflammatory diseases and neuroprotection. Publication expected.

Qualifications

• PhD in Biochemistry, Neuroscience, Molecular Biology, Cell Biology, or a closely related life sciences field.
• Demonstrated in-depth experience with LC-MS/MS-based lipidomics, metabolomics, and/or proteomics assay development and quantification.
• Experience with immunoproteomic, ELISA, or ligand-binding assay (LBA) techniques, and PCR/qPCR/ddPCR for transcript quantification.
• Authorized to work in the United States on a full-time basis.

Responsibilities

• Lead the design, development, optimization, and execution of LC-MS–based assays to quantify biomarkers of lysosomal health and degradative capacity across peripheral, pulmonary, and CNS tissues.
• Generate and interpret data to characterize modules governing autophagy, cargo receptors, lysosomal biogenesis, and lysosomal lipid metabolism; cross-validate hits in vitro and in vivo.
• Collaborate with the extended research team to design and execute in vivo and in vitro studies on lysosomal homeostasis in metabolic status, chronic inflammation, and neurodegeneration.
• Identify peripheral and tissue-specific biomarkers and support translational rationale for future clinical studies.

Skills

LC-MS lipidomics/metabolomics

Proteomics

Immunoproteomics / LBA

Transcriptomics

Data analysis & visualization

In vivo study design

Scientific collaboration

Education

PhD in Biochemistry/Neuroscience/Molecular Biology/Cell Biology (or related life sciences)

Tools

LC-MS/MS

Immunoproteomics / ELISA / LBA

PCR/qPCR/ddPCR

RNAseq

Job description

Eli Lilly and Company in Boston invites applications for a Postdoctoral Scientist in the Lilly Gene Therapy (LGT) organization. The role focuses on lysosomal biology and metabolic regulation using multi-omics across tissues, including CNS and peripheral sites.

You will lead LC-MS–based lipidomics, metabolomics, and proteomics studies, integrate transcriptomic data, and contribute to mechanistic understanding of lysosomal health in inflammatory diseases and neuroprotection. Publication expected.