Postdoc: Lysosomal Biology & Neuroprotection—Multi-Omics

Initial Therapeutics, Inc.

Boston (MA)

On-site

USD 58,000 - 123,000

Full time

14 days+

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Job summary

Lilly is seeking a highly motivated Postdoctoral Scientist to join the Lilly Gene Therapy (LGT) organization, with a primary focus on lysosomal biology and its role in metabolic regulation and cellular protection. This fixed-term role offers hands-on preclinical studies and multi-omics approaches, with opportunities for publication in peer‑reviewed journals.

Based in Boston, MA, the role requires daily on-site presence in the lab and collaboration across cross-functional teams.

Qualifications

PhD in Biochemistry, Neuroscience, Molecular Biology, Cell Biology, or a closely related life sciences field.
Demonstrated in-depth experience with LC-MS/MS-based lipidomics, metabolomics, and/or proteomics assay development and quantification.
Experience with immunoproteomic, ELISA, or ligand-binding assay (LBA) techniques, and PCR/qPCR/ddPCR for transcript quantification.
Authorized to work in the United States on a full-time basis.

Responsibilities

Lead the design, development, optimization, and execution of LC-MS–based, immunoproteomics, and ligand‑binding assays to quantify biomarkers of lysosomal health across tissues.
Generate and interpret data to characterize modules governing autophagy, lysosomal biogenesis, and lipid metabolism; validate hits in vitro and in vivo.
Collaborate to design in vivo and in vitro studies; troubleshoot technical challenges in assays and tissue processing.
Identify peripheral and tissue biomarkers; support validation against human datasets; maintain meticulous documentation.
Create data visualizations and communicate findings through presentations and publications.