Postdoc: Immunology for Senolytic in Lung Fibrosis

BioSpace; San Francisco (CA); On-site; USD 58,000 - 123,000; Full time

Job summary

Lilly is seeking a postdoctoral scientist to join a high-visibility research program at the intersection of cellular senescence, fibrosis, and immune-based therapeutics. The role spans cellular models, in vivo fibrosis models, and human tissue, aiming to establish a precision senolytic approach that selectively eliminates pathological senescent cells in the fibrotic lung.

The candidate will establish models, validate markers, develop immune strategies, and evaluate efficacy across tissues,

Qualifications

• PhD in Immunology, Cell Biology, Molecular Biology, Aging Biology, or a closely related field.
• Experience with cellular senescence and at least one of: fibrosis, aging biology, immunology, therapeutic modality engineering, or relevant analytical approaches such as proteomics or single-cell analysis.
• Strong publication record demonstrating scientific productivity and independence.

Responsibilities

• Establish and characterize models of cellular senescence relevant to fibrotic lung disease, spanning primary human cells, iPSC-derived cells, and in vivo fibrosis models.
• Identify and validate cell-surface markers distinguishing pathological senescent cells from healthy tissue, prioritizing candidates with a favorable safety profile.
• Develop immune effector-based strategies to selectively eliminate senescent cells in the fibrotic lung.
• Evaluate senolytic efficacy and its impact on fibrosis across disease-relevant human tissue and in vivo models.
• Collaborate with cross-functional teams and external academic partners, present findings at major scientific conferences, and publish as first author.

Skills

Immunology

Cell Biology

Aging Biology

Education

PhD in Immunology or related field

Tools

Proteomics

Single-cell analysis

In vivo models

Job description

Lilly is seeking a postdoctoral scientist to join a high-visibility research program at the intersection of cellular senescence, fibrosis, and immune-based therapeutics. The role spans cellular models, in vivo fibrosis models, and human tissue, aiming to establish a precision senolytic approach that selectively eliminates pathological senescent cells in the fibrotic lung.

The candidate will establish models, validate markers, develop immune strategies, and evaluate efficacy across tissues,