Platform Innovation Scientist I

Basecamp Research; Cambridge (MA); On-site; USD 110,000 - 140,000; Full time

Job summary

Basecamp Research in Cambridge, MA is seeking a Scientist I, Platform Innovation to establish a new lab and develop transformative solutions in gene editing and cellular engineering.

You will work closely with our Data Science and AI teams to tackle unique challenges, using cutting-edge tools and high-throughput screening to advance therapeutic discoveries.

This role offers collaboration across biology, engineering, and computation in a fast-growing biotech.

Qualifications

• PhD in molecular biology, biochemistry, genetics, bioengineering or life-sciences field, or MSc with hands-on lab experience.
• Experience with gene editing, NGS assay development, protein engineering and cell therapy.
• Experience with high-throughput cloning and producing DNA constructs for cellular screening.
• Experience with mammalian cell culture, transfection, and cell-line generation.
• Knowledge of emerging technologies in gene editing and on/off-target analytics for regulatory approval.
• Expertise with DNA/RNA extraction, PCR, ddPCR, NGS library prep and QC.
• Excellent communication skills to internal and external stakeholders.

Responsibilities

• Contribute to establishing a new screening platform for discovery and engineering of novel gene editing tools.
• Contribute to design, build, test cycles of novel protein enzymes with emphasis on discovery, validation and engineering of gene editing tools.
• Build and screen plasmid libraries and develop cloning workflows at scale.
• Quantify editing outcomes using ddPCR, qPCR, flow-cytometry and NGS readouts.
• Optimize hits for activity and specificity using human primary cells and cell lines to develop leads.
• Contribute to an open and high-integrity scientific culture at Basecamp Research.
• Establish strong documentation practices and lab SOPs as a founding member of the lab team.

Skills

Gene editing

NGS assay development

Protein engineering

Cell therapy

High-throughput cloning

Mammalian cell culture

Transfection

DNA/RNA extraction

PCR

ddPCR

NGS library preparation

Communication

Education

PhD in molecular biology

PhD in biochemistry

PhD in genetics

PhD in bioengineering

MSc with hands-on lab experience

Tools

Flow cytometer

Job description

Basecamp Research in Cambridge, MA is seeking a Scientist I, Platform Innovation to establish a new lab and develop transformative solutions in gene editing and cellular engineering.

You will work closely with our Data Science and AI teams to tackle unique challenges, using cutting-edge tools and high-throughput screening to advance therapeutic discoveries.

This role offers collaboration across biology, engineering, and computation in a fast-growing biotech.