Associate Scientist II – Oligonucleotide Process Development

Proclinical Group; Cambridge (MA); On-site; USD 55,000 - 83,000; Part time

Job summary

Proclinical Group in Cambridge, MA is seeking an Associate Scientist II on a contract basis to join the CMC - DS Process Development Group. The role focuses on integrating novel chemistries into the oligonucleotide manufacturing platform and advancing process development.

The ideal candidate has a BS in Chemistry or Chemical Engineering, hands-on analytical lab experience, and proficiency with LC/HPLC, pH, osmolality and LC-MS.

Qualifications

• BS in Chemistry or Chemical Engineering required.
• Process development experience in chemical manufacturing.
• Strong analytical chemistry background with hands-on lab work.
• Experience running LC/HPLC analyses.
• Familiarity with pH, Osmolality, Conductivity, LC-MS.
• Excellent lab documentation and data recording.
• Knowledge of oligonucleotide manufacturing including Phosphoramidite chemistry

Responsibilities

• Support synthesis method development, optimization, and scale-up.
• Support downstream processing method development.
• Execute in-process analytical testing.
• Collaborate with researchers to develop robust processes for novel chemistries.
• Maintain accurate laboratory documentation.
• Maintain a safe and orderly lab environment.
• Assist with routine lab and equipment maintenance.

Skills

Analytical chemistry

Laboratory techniques

Documentation

Data recording

LC-HPLC

Oligonucleotide knowledge

Education

BS in Chemistry or Chemical Engineering

Tools

Agilent UNICORN software

LC-MS instrumentation

Job description

Proclinical Group in Cambridge, MA is seeking an Associate Scientist II on a contract basis to join the CMC - DS Process Development Group. The role focuses on integrating novel chemistries into the oligonucleotide manufacturing platform and advancing process development.

The ideal candidate has a BS in Chemistry or Chemical Engineering, hands-on analytical lab experience, and proficiency with LC/HPLC, pH, osmolality and LC-MS.