NPI Scientist - Antibody Conjugation & Scale-Up

Nautilus Biotechnology; San Carlos (CA); On-site; USD 126,000 - 182,000; Full time

Job summary

Nautilus Biotechnology in San Carlos, CA is seeking a Scientist or Senior NPI Scientist who will bridge R&D and manufacturing, developing and refining production and testing methods for antibodies and related reagents. You will drive scale-up, technology transfer, and process validation, draft SOPs, and help resolve issues to ensure smooth transfers.

The role requires hands-on lab work and strong protein chemistry background.

Qualifications

• PhD in chemistry/biochemistry/molecular biology with 2–3 years of industry experience, or MS with 3–5 years, or BS with 5–7+ years.
• Deep knowledge of protein biochemistry, purification, reagent formulation, or analytical chemistry (HPLC, MS, FPLC).
• Experience in BOM setup using Arena/Agile, costing analysis, supply chain setup, vendor management.
• Hands-on experience in controlled development or manufacturing environments (ISO9001 & ISO 13485).
• Strong interpersonal and communication skills, with the ability to document processes clearly and train others to execute SOPs.
• Proficiency in Excel; familiarity with Smartsheet, Microsoft Project, or similar.
• Willingness to work hands-on in the lab and production environment; project management skills to meet timelines.

Responsibilities

• Own the transfer of newly developed biochemical reagents, proteins, antibodies and sequencing assays from R&D phase to commercial.
• Design, develop and optimize scale-up studies, improve yield, stability and robustness of complex formulations and processes.
• Author documents including SOPs, batch records, and technical reports, while ensuring compliance with quality standard.
• Conduct root-cause analysis and provide technical support to resolve production-line anomalies during pilot and production phases.
• Partnering with the R&D to help establish QC release criteria and specifications for all manufactured reagents.
• Performing hands-on laboratory and production work, including reagent formulation, conjugation, and analytical sample preparation.

Skills

Protein biochemistry

Protein purification

Reagent formulation

Analytical chemistry

HPLC

MS

FPLC

BOM setup

Arena/Agile

Costing analysis

Supply chain setup

Vendor management

ISO9001/ISO13485

Excel

Smartsheet

Microsoft Project

Project management

Laboratory hands-on

Education

PhD in chemistry/biochemistry/molecular biology

MS in related field

BS with extensive industry experience

Tools

Arena/Agile

Smartsheet

Microsoft Project

Job description

Nautilus Biotechnology in San Carlos, CA is seeking a Scientist or Senior NPI Scientist who will bridge R&D and manufacturing, developing and refining production and testing methods for antibodies and related reagents. You will drive scale-up, technology transfer, and process validation, draft SOPs, and help resolve issues to ensure smooth transfers.

The role requires hands-on lab work and strong protein chemistry background.