Neuroscience Scientist — iPSC Neuron Discovery

Socket.dev; Cambridge (MA); On-site; USD 125,000 - 150,000; Full time

Benefits offered by this job

Medical, dental & vision

Life & disability insurance

Parental leave

401(k) with company contribution

Employee stock purchase program

Trek Time (flexible time off)

Tuition assistance

Job summary

CAMP4 Therapeutics is seeking a Scientist I/II to join the Discovery team in Watertown, MA, focusing on functional and phenotypic assays in human iPSC-derived neurons to advance CNS programs. You will work with MEA, calcium imaging, and high-content imaging to characterize disease-relevant phenotypes and ASO rescue effects.

The role involves designing and executing experiments, collaborating across disciplines, and maintaining thorough records for regulatory submissions.

Qualifications

• PhD in neuroscience, molecular biology, cell biology, or a related discipline; 0–3 years post-degree experience.
• Hands-on experience with neuronal functional or phenotypic assays (MEA, calcium imaging, high-content imaging).
• Strong mammalian cell culture skills in human iPSC-derived neurons or related systems.

Responsibilities

• Develop, optimize, and implement functional and phenotypic assays in human iPSC-derived neurons (MEA, calcium imaging, high-content imaging).
• Establish disease-relevant neuronal phenotypes and evaluate responses to candidate ASOs.
• Design experiments for target validation and selection across CNS programs.
• Develop cellular and biochemical assays to assess target engagement and downstream effects of ASOs.
• Analyze, interpret, and communicate results to project teams and stakeholders.
• Collaborate cross-functionally to integrate assay data with molecular and genomic information.
• Maintain detailed records for regulatory documentation of ASOs.

Skills

MEA

Calcium imaging

High-content imaging

Mammalian cell culture

Immunofluorescence

Quantitative analysis

Experimental design

Data interpretation

Education

PhD in neuroscience or related field

Job description

CAMP4 Therapeutics is seeking a Scientist I/II to join the Discovery team in Watertown, MA, focusing on functional and phenotypic assays in human iPSC-derived neurons to advance CNS programs. You will work with MEA, calcium imaging, and high-content imaging to characterize disease-relevant phenotypes and ASO rescue effects.

The role involves designing and executing experiments, collaborating across disciplines, and maintaining thorough records for regulatory submissions.