iPSC Neuroscience Discovery Scientist & Assay Developer

Genentech; South San Francisco (CA); On-site; USD 86,000 - 159,000; Full time

Benefits offered by this job

Relocation benefits

Job summary

Genentech, located in South San Francisco, CA, seeks a Scientist 2, Neuroscience Discovery & iPSC Assay Development to advance discovery research using human iPSCs to model CNS cell types and perform functional assays.

You will support genetic and pharmacological proof-of-concept studies, generate and analyze complex data, and present findings to multidisciplinary teams, while maintaining ELN records and lab operations. relocation benefits apply, with salary range $85,500–$158,700.

Qualifications

• Bachelor's degree in Cell Biology, Molecular Biology, Neuroscience, or a related field with 6+ years of laboratory experience, OR a Master's degree with 4+ years of experience in iPSC and mammalian cell culture.
• Demonstrated technical proficiency in human iPSC maintenance, banking, quality control, and directed differentiation into CNS cell types (neurons, microglia, astrocytes, or oligodendrocytes).
• Hands-on expertise in molecular biology, advanced optical imaging, biochemistry, molecular profiling, and executing plate-based or high-content imaging assays.
• Strong skills in independent experimental design, organization, critical thinking, and written/verbal communication.
• Preferred: Familiarity or hands-on experience with CRISPR/Cas9 gene editing, arrayed/pooled CRISPR screens, or single-cell RNA sequencing (scRNA-seq) workflows.

Responsibilities

• Perform culture, banking, and quality control of human iPSCs, and differentiate iPSCs into CNS cell lineages (neurons, glia) following established protocols.
• Manage and maintain routine primary neuronal cultures to support comparative and complementary functional studies.
• Design, optimize, and execute robust cell-based assays supporting neuroscience pipeline programs, implementing new technology platforms when needed.
• Support genetic and pharmacological proof-of-concept studies through precise execution of experimental workflows.
• Generate, analyze, and document complex experimental data with a focus on high reproducibility, maintaining accurate Electronic Lab Notebook (ELN) records.
• Present scientific findings and actionable insights to multidisciplinary project teams via reports, presentations, and team discussions.
• Oversee iPSC lab operations, ensuring efficient shared reagent management, equipment maintenance, and adherence to safety protocols.

Skills

iPSC culture

Neuroscience

Data analysis

Experimental design

CRISPR editing

Imaging techniques

Education

Bachelor's degree in Cell Biology or related

Master's degree in related field

Tools

CRISPR tools

High-content imaging

NGS workflows

Python/R

Job description

Genentech, located in South San Francisco, CA, seeks a Scientist 2, Neuroscience Discovery & iPSC Assay Development to advance discovery research using human iPSCs to model CNS cell types and perform functional assays.

You will support genetic and pharmacological proof-of-concept studies, generate and analyze complex data, and present findings to multidisciplinary teams, while maintaining ELN records and lab operations. relocation benefits apply, with salary range $85,500–$158,700.