Senior Scientist, In Vitro Neuropharmacology & Screening

Bristol-Myers Squibb Co; Cambridge (MA); Sur place; USD 105 000 - 127 000; Plein temps

Résumé du poste

Bristol Myers Squibb is seeking a detail-oriented scientist to support high-throughput screening in our neuroscience drug discovery group. You will develop scalable assays and execute screening campaigns to identify novel targets and modulators.

The role emphasizes cell-based assays, genetic perturbation, and data-driven decision making in a fast-paced environment with rigorous quality standards.

Qualifications

• Bachelor's degree in Biology, Neuroscience, Pharmacology, Biochemistry, or a related field with 4+ years of relevant experience, or a Master's with 2+ years.
• Hands-on experience with mammalian cell culture and high-throughput screening workflows.
• Experience in assay development, genetic perturbation, and data-driven decision making.

Responsabilités

• Develop, optimize, and validate assays for high-throughput and high-content screening applications.
• Execute compound screening campaigns, including cell viability and reporter-based assays.
• Design and implement genetic perturbation screens (e.g., siRNA/ASO, CRISPR-based) to support therapeutic discovery.
• Perform high-content imaging and automated image analysis to extract quantitative phenotypic data.
• Maintain and scale mammalian cell culture systems to support screening throughput.
• Troubleshoot assay performance issues and implement process improvements to ensure data quality and reproducibility.
• Analyze large screening datasets and visualize results to support go/no-go decisions.
• Document protocols and results in accordance with scientific and quality standards.
• Partner cross-functionally with automation, informatics, and target validation teams to advance screening pipelines.

Connaissances

High-throughput screening

Assay development

Genetic perturbation

Cell culture

Data analysis

CRISPR methods

Formation

Bachelor's degree in Biology/Neuroscience/Biochemistry

Master's degree in related field

Outils

Automation platforms

High-content imaging systems

siRNA/ASO techniques

Description du poste

Bristol Myers Squibb is seeking a detail-oriented scientist to support high-throughput screening in our neuroscience drug discovery group. You will develop scalable assays and execute screening campaigns to identify novel targets and modulators.

The role emphasizes cell-based assays, genetic perturbation, and data-driven decision making in a fast-paced environment with rigorous quality standards.