Neurogenomics Research Assistant II

The Scripps Research Institute; San Diego (CA); On-site; USD 70,000 - 77,000; Full time

Benefits offered by this job

Retirement plan

Health & welfare plans

HSA option

Flexible spending accounts

Vacation & sick leave

On-site parking

Job summary

The Scripps Research Institute in La Jolla, CA, is seeking a Research Assistant II to support studies using genomic tools to investigate brain development and neurodevelopmental disease mechanisms. The role involves mouse handling, molecular biology, genomics, cell culture, and single-cell sequencing workflows.

You will work both independently and collaboratively to perform experiments, maintain accurate records, troubleshoot protocols, and help generate high-quality data for ongoing research

Qualifications

• Requires a bachelor’s degree in a relevant scientific discipline or equivalent experience.
• Requires 3–5 years' experience; master’s degree may reduce experience requirements.
• Experience with mouse handling, colony management, tissue collection, genotyping or related animal research procedures.
• Experience with standard molecular biology techniques such as DNA/RNA extraction, PCR, qPCR, gel electrophoresis, cloning, or sequencing sample prep.
• Experience with mammalian cell culture, sterile technique, transfection or viral transduction, or cell-based assays.
• Familiarity with genomics or single-cell sequencing workflows preferred.
• Ability to follow detailed protocols, maintain organized records, and track samples and reagents.
• Ability to work independently, troubleshoot issues, and adapt procedures as needed.

Responsibilities

• Perform lab work involving mouse handling, molecular biology, genomics, and cell culture to support brain development studies.
• Assist with CRISPR-based perturbation experiments, including reagent prep, viral/vector workflows, sample collection, and downstream analysis.
• Handle and monitor mice, tissue collection, and experimental prep.
• Carry out mouse procedures such as colony tracking, genotyping, tissue dissection, and brain sample preparation for analysis.
• Perform DNA/RNA extraction, PCR, qPCR, gel electrophoresis, cloning, and sequencing-related prep.
• Support single-cell genomics workflows, including nuclei/cell prep, QC, library prep, and sequencing submission.
• Maintain mammalian cell cultures with sterile techniques, including passaging, transfection, and monitoring cell health.
• Prepare and validate reagents such as plasmids, oligos, guide RNA libraries, buffers, and media.
• Record procedures, sample info, and results in notebooks and databases.

Skills

Mouse handling

Molecular biology

Genomics

Single-cell sequencing

Cell culture

CRISPR workflows

Record keeping

Troubleshooting

Education

Bachelor's degree

Master's degree preferred

Tools

PCR

qPCR

Gel electrophoresis

Cloning

DNA/RNA extraction

Job description

The Scripps Research Institute in La Jolla, CA, is seeking a Research Assistant II to support studies using genomic tools to investigate brain development and neurodevelopmental disease mechanisms. The role involves mouse handling, molecular biology, genomics, cell culture, and single-cell sequencing workflows.

You will work both independently and collaboratively to perform experiments, maintain accurate records, troubleshoot protocols, and help generate high-quality data for ongoing research