Neurodegenerative Gene Therapy Research Specialist

University of Pennsylvania; Arizona; On-site; USD 45,000 - 60,000; Full time

Job summary

The Amado Laboratory, a part of both the Perelman School of Medicine at the University of Pennsylvania and the Children\'s Hospital of Philadelphia, seeks a highly motivated Research Specialist A/B to join our program focused on gene therapy for ALS and related disorders. You will work with cell lines, patient-derived cells, and mouse models.

Experience in basic lab techniques and literature review is valued; the role emphasizes organization, data analysis, and collaboration in a fun

Qualifications

• RS-A: Bachelor of Science and 0 to 1 year of experience or equivalent combination of education and experience is required.
• RS-B: Bachelor of Science and 1 to 2 years of experience or equivalent combination of education and experience is required.
• Prior experience with mammalian cell culture (including transfection) and molecular/cell biology is preferred.
• Prior experience with mice is preferred; openness to it is required.
• Ability to work both independently and as part of a team is required.
• Excellent organizational, time management, and critical thinking skills are required.

Responsibilities

• Design, conduct, and analyze experiments in immortalized cell lines, patient-derived stem cells, and mouse models.
• Read published literature to identify effective, reliable, and novel strategies to advance projects.
• Assist with tissue extraction, behavior testing, and in vivo components as needed.
• Maintain careful records and documentation of experimental procedures and results.

Skills

Mammalian cell culture

Molecular/cell biology

Mouse handling

Transfection

QPCR

Western blotting

Molecular cloning

Cell culture techniques

Education

Bachelor of Science

Tools

AAV-mediated gene delivery

RNA interference

Gene editing

ASOs

Job description

The Amado Laboratory, a part of both the Perelman School of Medicine at the University of Pennsylvania and the Children\'s Hospital of Philadelphia, seeks a highly motivated Research Specialist A/B to join our program focused on gene therapy for ALS and related disorders. You will work with cell lines, patient-derived cells, and mouse models.

Experience in basic lab techniques and literature review is valued; the role emphasizes organization, data analysis, and collaboration in a fun