Scientist, Mass Spectrometry

Spectraforce; South San Francisco (CA); Sur place; USD 120 000 - 180 000; Plein temps

Résumé du poste

Spectraforce is seeking a Mass Spectrometry Automation Engineer/Scientist II to join the Bay Area Biotherapeutics group in South San Francisco. The role combines analytical instrumentation with software automation to support production and characterization of biologics.

The candidate will work on intact, reduced, and subunit MS analyses, maintain LC/MS systems, and collaborate across R&D to implement new bioanalytical technology. Strong programming and data skills are required.

Qualifications

• Experience with MS platforms and protein characterization workflows.
• Proficiency in data processing and bioinformatics workflows.
• Coding or scripting ability in Python or R for automated data workflows.

Responsabilités

• Perform MS analyses for biologics characterization (intact, reduced, subunit).
• Maintain LC/MS equipment and troubleshoot to ensure peak performance.
• Guide production of biotherapeutic proteins to CRO vendors and report results to partners.
• Collaborate with MS experts and present findings to colleagues and stakeholders.
• Contribute to method development and new bioanalytical tech assessments.

Connaissances

Mass spectrometry

Automation programming

Data analysis

Team collaboration

Communication skills

Formation

BS in Chemistry/Biochemistry

MS in Chemistry/Biochemistry

PhD in related discipline

Outils

Waters Xevo G2-XS QToF

Protein Metrics

Biosphere

Waters Connect

UNIFI

HPLC/LCMS software

Python/R scripting

Description du poste

Position Title: Mass Spectrometry Automation Engineer / Scientist II

Duration: Minimum of 1 year

• We are looking for a combination of software automation, analytical instrumentation, and wet-lab experience.
• The ideal candidate does not need to be an expert in every mass spec platform (experience with Waters Xevo LC/MS instruments and Protein Metrics analytics software is highly desirable) but should be able to understand instrument workflows and build reliable automation around them.
• In particular, the hiring manager would like to hear a story or vignettes on how you merged your mass spectrometry expertise and understanding of antibody-based biologics to make critical decisions that drive programs forward.
• Discovery Biotherapeutics and Genetic Medicine (BGM) at is seeking a highly motivated scientist to join the Biotherapeutics group at the Bay Area (ABA) site in South San Francisco.
• This role offers a unique opportunity to contribute to various Discovery Research Therapeutic Areas (TAs) and projects by providing production and analytical characterization of biologics and biopharmaceutical products, such as monoclonal antibodies, multi-specifics, and other antibody-like formats. As part of our team, your work will drive the discovery and development of next generation biologics through production and interrogation of protein attributes.

Key responsibilities:

• Conduct mass spectrometry analyses for comprehensive characterization of biologics and biotherapeutics, including intact, reduced, and subunit approaches.
• Ensure the optimal functioning of LC/MS equipment through routine maintenance and effective troubleshooting.
• Design and execute production of biotherapeutic proteins to external CRO vendors, provide guidance on desired product quality attributes, then deliver the results of the production to our therapeutic partners.
• Contribute to team discussions, share valuable insights, and present experimental findings and progress updates to colleagues and stakeholders.
• Collaborates with MS experts across our Research & Development Division to assess and implement new bioanalytical technology.
• Independently and autonomously perform laboratory research and method development with minimal supervision, demonstrating high productivity and scientific initiative

Qualifications:

• BS, MS, or PhD in chemistry, biochemistry, or related discipline with typically 7+ (BS), 5+ (MS), or 0+ (PhD) years of relevant experience.
• Demonstrated hands-on expertise with various mass spectrometry platforms, including Waters Xevo G2-XS QToF, along with proficiency in MS workflows for protein characterization and the use of MS software for analyzing both routine and complex datasets.
• Proficiency in data processing and bioinformatic and statistical workflows (e.g., Protein Metrics, Biosphere, Waters Connect, UNIFI)
• Proven experience in the application of LC/MS analyses for interrogation of monoclonal antibodies, multispecific biologics, and protein therapeutics to provide sequence verification, post-translational modification, desired/expected chain pairing, and identity of DLP profile.
• Experience with coding/programming (e.g., Python, R, or relevant scripting languages) and in developing automated data workflows or solutions.
• Experience with chromatography and purification systems (protein A/G, AEX, SEC, mixed-mode with AKTA systems), and analytical instruments (Agilent HPLC, Waters UPLC and LC/MS, CE-SDS, SDS-PAGE) is a plus
• Goal-oriented team player with excellent verbal and written communication skills, a strong positive attitude, and the ability to thrive in a fast-paced, multidisciplinary environment.

For information on benefits, equal opportunity employment, and location-specific applicant notices. Click here: https://spectraforce.com/spectraforce-applicant-disclaimers-contingent/

At SPECTRAFORCE, we are committed to maintaining a workplace that ensures fair compensation and wage transparency in adherence with all applicable state and local laws.