LNP Formulation Scientist, Preclinical & Pilot Manufacturing

Sendabiosciences; Cambridge (MA); On-site; USD 95,000 - 120,000; Full time

Job summary

Sail Biomedicines in Cambridge, MA is seeking a scientist to advance our lipid nanoparticle manufacturing platform for nucleic acid therapeutics. You will develop and operationalize LNP formulations at pre-clinical and pilot lab scales, contributing to preclinical programs at the interface of manufacturing, formulation science, analytics, and process development.

The role requires hands-on LNP formulation, data generation, documentation, and collaboration with analytical and platform teams to

Qualifications

• 4+ years (M.Sc.) or 6+ years (B.Sc.) in LNP formulation optimization.
• Hands-on experience in nanoparticle formulation and characterization.
• Strong background in nucleic acid therapeutics and related education.
• Ability to design, execute, and troubleshoot experiments independently.

Responsibilities

• Design, formulate, and characterize lipid nanoparticle systems for nucleic acid delivery across preclinical stages.
• Develop, optimize and operationalize formulation processes and scale-up approaches (e.g., TFF, ultrafiltration).
• Troubleshoot formulation and process challenges to improve robustness and reproducibility.
• Generate high-quality, reproducible data and maintain thorough documentation in electronic lab notebooks.
• Prepare LNP formulations to support internal research and partner programs.
• Collaborate cross-functionally with analytical, translational and platform teams to advance preclinical manufacturing goals.
• Present data and insights clearly to internal teams and contribute to scientific discussions.

Skills

LNP formulation

Nanoparticle characterization

Nucleic acid therapeutics

Data analysis

Independent experimentation

DLS

Zeta potential

Education

M.Sc. in Life Sciences or Engineering

6+ years with B.Sc. alternative

Tools

DLS

Zeta potential

Chromatography

Ultrafiltration

Job description

Sail Biomedicines in Cambridge, MA is seeking a scientist to advance our lipid nanoparticle manufacturing platform for nucleic acid therapeutics. You will develop and operationalize LNP formulations at pre-clinical and pilot lab scales, contributing to preclinical programs at the interface of manufacturing, formulation science, analytics, and process development.

The role requires hands-on LNP formulation, data generation, documentation, and collaboration with analytical and platform teams to