Associate Scientist, Formulation, Pilot Lab

Sail Biomedicines; Cambridge (MA); On-site; USD 95,000 - 120,000; Full time

Job summary

Sail Biomedicines is seeking a scientist to advance our lipid nanoparticle (LNP) manufacturing platform for nucleic acid therapeutics. Sail Biomedicines is seeking a highly talented and self-motivated individual to develop and operationalize lipid nanoparticle formulations at pre-clinical and pilot lab scales.

The successful candidate will contribute to preclinical pipeline programs, working at interface of manufacturing, formulation science, analytical characterization, and process development.

Qualifications

• 4 years (M.Sc.) or 6 years (B.Sc.) of relevant industry experience in LNP formulation optimizations.
• Strong background in nucleic acid therapeutics and education in life sciences or engineering.
• Hands-on experience with nanoparticle or LNP formulation and characterization.
• Experience with nanoparticle characterization techniques (DLS, zeta potential, fluorescence-based assays).
• Ability to design, execute, and troubleshoot experiments independently.

Responsibilities

• Design, formulate, and characterize lipid nanoparticle (LNP) systems for nucleic acid delivery across preclinical manufacturing and technology development stages.
• Develop, optimize and operationalize formulation processes and scale-up approaches (e.g., TFF, ultrafiltration).
• Troubleshoot formulation and process challenges to enhance robustness, reproducibility, and scalability.
• Generate high-quality, reproducible data and maintain thorough documentation in electronic lab notebooks.
• Prepare LNP formulations to support internal research and partner programs.
• Collaborate cross-functionally with analytical, translational and platform teams to advance pre-clincial manufacturing and pilot lab goals.
• Present data and insights clearly to internal teams and contribute to scientific discussions and decision-making.

Skills

LNP formulation

Drug delivery systems

Nanoparticle characterization

Independent experimentation

Data analysis and documentation

Education

Master of Science in Pharmaceutical Sciences or Biomedical Engineering

Bachelor of Science in Life Sciences or Engineering

Tools

DLS

Zeta potential

Ribogreen assay

Chromatography

Job description

Sail Biomedicines is seeking a scientist to advance our lipid nanoparticle (LNP) manufacturing platform for nucleic acid therapeutics. Sail Biomedicines is seeking a highly talented and self-motivated individual to develop and operationalize lipid nanoparticle formulations at pre-clinical and pilot lab scales. The successful candidate will contribute to preclinical pipeline programs, working at interface of manufacturing, formulation science, analytical characterization, and process development.

KEY RESPONSIBILITIES

• Design, formulate, and characterize lipid nanoparticle (LNP) systems for nucleic acid delivery across preclinical manufacturing and technology development stages.
• Develop, optimize and operationalize formulation processes and scale-up approaches (e.g., TFF, ultrafiltration)
• Troubleshoot formulation and process challenges to enhance robustness, reproducibility, and scalability
• Generate high-quality, reproducible data and maintain thorough documentation in electronic lab notebooks
• Prepare LNP formulations to support internal research and partner programs
• Collaborate cross-functionally with analytical, translational and platform teams to advance pre-clincial manufacturing and pilot lab goals
• Present data and insights clearly to internal teams and contribute to scientific discussions and decision-making

PROFESSIONAL EXPERIENCE & QUALIFICATIONS

• 4 years (M.Sc.) or 6 years (B.Sc.) of relevant industry experience in LNP formulation optimizations and drug delivery with strong background in nucleic acid therapeutics and education in life sciences or engineering (Pharmaceutical Sciences, Biomedical Engineering, Biochemistry, etc)
• Level (Associate Scientist or Scientist I) will be determined based on experience, technical expertise, and demonstrated impact.
• Hands-on experience in nanoparticle or LNP formulation and characterization
• Strong understanding of drug delivery systems, particularly for nucleic acid therapeutics
• Experience with nanoparticle characterization techniques (e.g., DLS, zeta potential, fluorescence-based assays such as Ribogreen, chromatography)
• Demonstrated ability to design, execute, and troubleshoot experiments independently
• Strong data analysis, documentation, and communication skills

PREFERRED QUALIFICATIONS

• Familiarity with formulation process technologies (e.g., microfluidic mixers, pumping systems, TFF)
• Experience supporting in vivo studies or translating formulations from research to preclinical scale

Salary Range: $95,000 – $120,000

Sail Biomedicines is an Equal Opportunity Employer. Sail does not discriminate based on race, religion, color, sex, gender identity, sexual orientation, age, national origin, veteran status, or any other status protected under federal, state, or local law.