Lead Principal Scientist, Oral Formulation & Tech Transfer

Biogen; Cambridge (MA); On-site; USD 159,000 - 219,000; Full time

Benefits offered by this job

Medical, Dental, Vision

Paid vacation

Stock options

Tuition reimbursement

Job summary

Biogen seeks a Principal Scientist, Oral Formulation Development in Cambridge, MA to provide scientific leadership for small molecule oral drug products. You will lead formulation and process development across clinical programs, enabling technologies, and technology transfer.

The role requires collaboration with regulatory CMC, manufacturing, and external partners, managing interfaces and advancing new workflows.

Qualifications

• PhD with 10+ years in oral drug product development.
• Proven track record leading formulation and process development for oral solids.
• Strong understanding of oral solid dose manufacturing operations.
• Experience with scale-up, tech transfer, clinical manufacturing, and external CMOs.
• Solid knowledge of CMC development and regulatory expectations.

Responsibilities

• Lead design, development, and tech transfer of small molecule oral dosage forms across development stages.
• Develop enabling formulation approaches for poorly soluble/poorly permeable or unstable compounds.
• Represent drug product on cross-functional CMC and asset teams to align regulatory, quality, and manufacturing.
• Assess developability/ manufacturability to influence portfolio decisions and investments.
• Oversee regulatory documentation and drug product sections for submissions.

Skills

Formulation leadership

Oral solid dosage

Cross-functional collaboration

CMC/regulatory knowledge

Scale-up & tech transfer

Education

PhD in Chemical Eng / Chemistry / Pharmaceutical Sci

Job description

Biogen seeks a Principal Scientist, Oral Formulation Development in Cambridge, MA to provide scientific leadership for small molecule oral drug products. You will lead formulation and process development across clinical programs, enabling technologies, and technology transfer.

The role requires collaboration with regulatory CMC, manufacturing, and external partners, managing interfaces and advancing new workflows.