Lead DMPK/ADME Scientist for Complex Modalities

Zealand Pharma U.S., Inc.; Cambridge (MA); On-site; USD 184,000 - 253,000; Full time

Job summary

Zealand Pharma U.S., Inc. is seeking a Principal Scientist to lead DMPK and bioanalysis capabilities in Cambridge, MA, shaping strategy and scientific excellence for complex modalities. You will drive discovery platforms and provide expert PK and metabolite insights to support nonclinical studies.

You will collaborate across cross‑functional teams and external CROs, delivering robust data packages and regulatory‑relevant documentation while advancing digital and automation‑enabled DMPK workflows.

Qualifications

• PhD in pharmaceutical sciences, biochemistry, chemistry or a related scientific field.
• 6+ years of relevant post-degree experience in DMPK/ADME (drug discovery, non-clinical studies) with complex modalities (antibody‑peptide conjugates, peptides, antibodies).
• Track record in PK study design, data interpretation, and translating DMPK insights into actionable project recommendations.
• Solid background in bioanalysis and assay development (LC-MS and ligand binding assays).
• Experience optimizing PK properties of peptides, antibodies, and conjugates.
• Background in ADME assays and metabolite ID.
• Experience working with external partners/CROs, including scientific oversight and quality‑focused execution.
• Experience contributing to regulatory‑relevant DMPK documentation (IND/CTA) is an advantage.

Responsibilities

• Drive DMPK/ADME strategy for complex drug modalities (e.g., antibodies, antibody‑peptide conjugates and peptides).
• Establish and grow DMPK discovery platforms and bioanalysis capabilities (LC-MS, immunoassays) to support PK, metabolite ID, and nonclinical study needs.
• Provide deep in vitro assay expertise across multiple modality formats, leading metabolic stability, binding considerations, and risk assessments.
• Oversee PK studies (internal and/or external) from design through assay development, data interpretation, and reporting.
• Deliver integrated DMPK summaries and high‑quality data packages to support project teams, governance milestones, and external documentation.
• Contribute to continuous improvement by adopting digital and automation‑enabled approaches within DMPK workflows.

Skills

DMPK leadership

ADME strategy

PK study design

Bioanalysis LC-MS

Ligand-binding assays

External partner oversight

Digital/automation DMPK workflows

Education

PhD in pharmaceutical sciences/biochemistry/chemistry

Tools

LC-MS

Job description

Zealand Pharma U.S., Inc. is seeking a Principal Scientist to lead DMPK and bioanalysis capabilities in Cambridge, MA, shaping strategy and scientific excellence for complex modalities. You will drive discovery platforms and provide expert PK and metabolite insights to support nonclinical studies.

You will collaborate across cross‑functional teams and external CROs, delivering robust data packages and regulatory‑relevant documentation while advancing digital and automation‑enabled DMPK workflows.