Director, DMPK & Translational PK Strategy

Denali Therapeutics Inc; South San Francisco (CA); On-site; USD 212,000 - 276,000; Full time

Benefits offered by this job

401k

healthcare coverage

ESPP

Job summary

Denali Therapeutics Inc. is seeking a senior DMPK leader to head the Nonclinical Safety Assessment and DMPK group, providing strategic vision for PK, drug disposition, and translational pharmacology across discovery to early clinical development.

You will guide SME-level decision-making, mentor staff, and collaborate with cross-functional teams to shape study designs and regulatory submissions. The role emphasizes leading cross-functional Project Teams, directing TK analyses for non-GLP/GLP

Qualifications

• PhD in Pharmacokinetics, Pharmaceutical Sciences, Pharmacology/Toxicology, Engineering, or a related field.
• 10+ years of relevant experience, including 8+ years of people management, mentorship, and coaching experience.
• Established expertise in biotherapeutic drug disposition and pharmacokinetics, with a track record identifying clinical candidates and advancing molecules through CTA/IND milestones to first-in-human trials.
• Proven ability to evaluate drug properties impacting PK, investigate PK/PD relationships, and apply relevant bioanalytical methods.

Responsibilities

• Lead and manage a group within the Nonclinical Safety Assessment and DMPK organization, providing strategic vision and oversight to advance candidates from Discovery through CTA/IND enabling studies.
• Contribute scientific expertise in PK, drug disposition, biodistribution, and translational pharmacology/PKPD to project teams.
• Lead Project Teams and Pharmacology Technical Teams to CTA/IND enabling stage and support regulatory filings.

Skills

PhD in Pharmacokinetics

People management

Drug disposition PK

Translational pharmacology

Education

PhD in a relevant field

Tools

Bioanalytical methods (ligand binding assays, mass spectrometry)

Job description

Denali Therapeutics Inc. is seeking a senior DMPK leader to head the Nonclinical Safety Assessment and DMPK group, providing strategic vision for PK, drug disposition, and translational pharmacology across discovery to early clinical development.

You will guide SME-level decision-making, mentor staff, and collaborate with cross-functional teams to shape study designs and regulatory submissions. The role emphasizes leading cross-functional Project Teams, directing TK analyses for non-GLP/GLP