Lead DMPK Scientist for IND-Enable Programs

General Proximity; San Francisco (CA); On-site; USD 180,000 - 280,000; Full time

Benefits offered by this job

Equity incentives

One Medical membership

Education and health/fitness incentive

Meditation retreats

Books budget

Lab at MBC BioLabs (135 Mississippi St

Job summary

General Proximity seeks a DMPK expert to lead drug metabolism and pharmacokinetics for a pioneering portfolio of induced proximity medicines. You will design and execute ADME and PK studies, interpret results, and communicate insights to project teams.

You will drive PK/PD modeling, IVIVC analyses, and support regulatory submissions with CRO oversight. You will work closely with medicinal chemistry, pharmacology, toxicology, and regulatory teams to advance programs from lead optimization through

Qualifications

• PhD in pharmacokinetics, pharmaceutical sciences, or related discipline.
• 3+ years in DMPK within drug discovery and development.
• Independent worker with cross-functional collaboration.
• Hands-on in vitro ADME and in vivo PK; translate data to insights.
• PK data analysis experience; familiarity with PK-PD concepts.

Responsibilities

• Lead DMPK, ADME, PK/PD modeling, and IND-enabling work.
• Design and interpret in vivo PK studies across portfolios.
• Coordinate CROs for DMPK studies and ensure data quality.
• Develop translational PK strategies and go/no-go guidance.

Skills

DMPK expertise

ADME in vitro

In vivo PK

PK/PD modeling

PBPK modeling

Bioanalytical LC-MS/MS

Regulatory submissions (IND/CTA)

Cross-functional collaboration

PK data analysis (Phoenix WinNonlin)

Team leadership

Education

PhD in pharmacokinetics or pharmaceutical sciences

Tools

Phoenix WinNonlin

Simcyp / GastroPlus

LC-MS/MS

Job description

General Proximity seeks a DMPK expert to lead drug metabolism and pharmacokinetics for a pioneering portfolio of induced proximity medicines. You will design and execute ADME and PK studies, interpret results, and communicate insights to project teams.

You will drive PK/PD modeling, IVIVC analyses, and support regulatory submissions with CRO oversight. You will work closely with medicinal chemistry, pharmacology, toxicology, and regulatory teams to advance programs from lead optimization through