LC-MS Analytical Chemist (siRNA) – Method Development

RXinsider LTD.; Cambridge (MA); On-site; USD 92,000 - 95,000; Full time

Benefits offered by this job

Medical insurance

Dental insurance

Vision insurance

401K plan

Paid time off

HSA

Wellness program

Tuition reimbursement

Employee Assistance program

Parental leave

ID theft protection

Job summary

Pace is seeking a Scientist to lead advanced analytical development with a focus on High-Resolution LC-MS for identification, characterization, and impurity profiling of siRNA molecules, formulations, and raw materials.

The role involves developing chromatographic methods (HPLC) and MS-based assays, authoring method development reports, and collaborating across internal and external teams to meet project timelines in a GMP environment.

Qualifications

• Bachelor’s or Master’s degree in Chemistry, Biology, or related field.
• 2-4 years of laboratory experience, GMP environment preferred.
• Excellent organizational, attention to detail, and communication skills.
• Experience with Agilent Q-ToF and MassHunter is a plus.

Responsibilities

• Hands-on bench work using the High-Resolution LC-MS.
• Development of chromatographic methods (HPLC) and mass spectrometric based assays for identification, characterization, and impurity determination of siRNA
• Develop strategies for impurity profiling of new development candidates and raw materials.
• Author method development and qualification reports and SOP’s for test methods.
• Evaluate suitability of new methods, and assist method qualification and validation.
• Contribute data to lead candidate testing, stability sample monitoring, OOS/deviation investigation and regulatory filing.
• Understand and apply advanced scientific principles, theories, concepts, practices and standards to process and analytical development.
• Follow training to independently operate instruments and carry out routine and non-routine analyses
• Collaborate with internal and external teams to support project goals and meet research timelines

Skills

Attention to detail

Organizational skills

Communication skills

Multitasking

Education

Bachelor’s or Master’s degree in Chemistry, Biology, or related field

Tools

Agilent Q-ToF

MassHunter

Office 365

Job description

Pace is seeking a Scientist to lead advanced analytical development with a focus on High-Resolution LC-MS for identification, characterization, and impurity profiling of siRNA molecules, formulations, and raw materials.

The role involves developing chromatographic methods (HPLC) and MS-based assays, authoring method development reports, and collaborating across internal and external teams to meet project timelines in a GMP environment.