Kilo-Scale Process Engineer for HPAPI & cGMP Ops

Scorpion Therapeutics; Indianapolis (IN); On-site; USD 85,000 - 110,000; Full time

Job summary

Scorpion Therapeutics in Indianapolis is seeking a chemical engineer to support API process engineering and development. You will evaluate scale-up feasibility, transfer gram- to kilogram-scale reactors, and collaborate with cross-functional teams.

The role involves designing and testing kilo-scale equipment, ensuring cGMP compliance, containment for HPAPI, and optimizing unit operations from crystallization to purification, with opportunities to advance in a growing biotech setting.

Qualifications

• BS or MS in chemical engineering with 1–4 years in pharma/biotech/CMO supporting API process engineering or development.
• Authorized to work in the United States full-time; no visa sponsorship.
• Experience with HPAPI handling/containment is preferred.

Responsibilities

• Evaluate scale-up feasibility and transfer gram- to kilogram-scale reactors using data and modeling.
• Design, test, and install equipment to meet evolving portfolio and reaction needs.
• Operate and troubleshoot kilo-scale reactor systems and support plant design.
• Engineer containment and safe-handling strategies for HPAPI operations.
• Optimize crystallization, distillation, extraction, and isolation operations.
• Ensure quality, safety, and cGMP compliance; document reports and notebooks.
• Drive cross-functional execution via risk assessments and project plans.
• Develop or review plans and timetables for project work.

Skills

Scale-up engineering

Kilo-scale equipment

Cross-functional

cGMP compliance

Process optimization

Regulatory documentation

Education

BS or MS in chemical engineering

Tools

DeltaV

Dynochem

Aspen Plus

Electronic Lab Notebook (ELN)

Job description

Scorpion Therapeutics in Indianapolis is seeking a chemical engineer to support API process engineering and development. You will evaluate scale-up feasibility, transfer gram- to kilogram-scale reactors, and collaborate with cross-functional teams.

The role involves designing and testing kilo-scale equipment, ensuring cGMP compliance, containment for HPAPI, and optimizing unit operations from crystallization to purification, with opportunities to advance in a growing biotech setting.