Junior Research Associate - Downstream

BioTalent; Tustin (CA); On-site; USD 55,000 - 75,000; Full time

Job summary

BioTalent is seeking a Junior Research Associate in Downstream Process Development in Tustin, CA. The role focuses on supporting downstream purification, chromatography development, filtration studies, and tech transfer activities to move processes toward manufacturing scale.

The successful candidate will contribute to protein purification, perform analytical testing, and assist with data interpretation and reporting for internal teams and clients.

Qualifications

• BS degree in biological sciences or related field.
• 1–2 years in downstream process development, protein purification, or bioprocessing.
• Hands-on chromatography, filtration, buffer prep, and protein purification techniques.

Responsibilities

• Support downstream process development and routine purification of antibodies and recombinant proteins.
• Assist chromatography method development and execution for purification processes.
• Perform buffer formulation development, buffer prep, and filtration process development.
• Operate chromatography systems, filtration equipment, and related instrumentation.
• Conduct in-process and analytical testing including protein concentration and HPLC assays.
• Compile, analyze, and interpret experimental data to support projects.

Skills

Downstream purification

Chromatography

Protein purification

Analytical testing

Education

B.S. in Biological Sciences/ Biotechnology/ Biochemistry/ Molecular Biology

Tools

HPLC

Filtration systems

Job description

Junior Research Associate, Process Development Downstream

Location: Tustin, CA

About the Role

We are partnering with a leading clinical and commercial biologics CDMO focused on developing and manufacturing biopharmaceuticals. They are seeking a Junior Research Associate, Process Development Downstream to support the development, optimization, and scale-up of downstream purification processes used in biologics manufacturing. This role offers the opportunity to contribute to protein purification, chromatography development, filtration studies, and technology transfer activities that help bring innovative therapies from development into commercial production.

Key Responsibilities

• Support downstream process development and routine purification of monoclonal antibodies and recombinant proteins.
• Assist with chromatography method development and execution for protein purification processes.
• Perform buffer formulation development, buffer preparation, and filtration process development activities.
• Operate chromatography systems, filtration equipment, and supporting process development instrumentation.
• Conduct in-process and routine analytical testing, including protein concentration and HPLC-based assays.
• Compile, analyze, and interpret experimental data to support process development projects.
• Prepare technical reports, presentations, and project summaries for internal teams and clients.
• Support process scale-up activities and technology transfer of downstream operations into manufacturing.

Qualifications & Requirements

• B.S. degree in Biological Sciences, Biotechnology, Biochemistry, Molecular Biology, or a related scientific discipline.
• 1-2 years of experience in downstream process development, protein purification, or bioprocessing.
• Hands-on experience with chromatography, filtration processes, buffer preparation, and protein purification techniques.

This position is not eligible for visa sponsorship or support such as H1B, TN, E-3, CPT, OPT, STEM OPT, or employment-based permanent residence processes, now or in the future.