Senior Research Process Development Downstream

BioTalent; Tustin (CA); On-site; USD 72,800 - 91,000; Full time

Benefits offered by this job

Health insurance

Dental insurance

Vision insurance

401(k) matching

Paid time off

Job summary

BioTalent in California is seeking a Senior Research Associate to lead downstream process development and purification for biopharmaceuticals, including monoclonal antibodies. You will oversee chromatography, filtration, and analytical testing, and mentor junior scientists in a fast-paced lab.

This onsite role offers competitive pay and comprehensive benefits. The position requires a strong background in downstream processing, experimental design, and data analysis, with a degree in a related

Qualifications

• Bachelor's degree with 3–4 years of biopharma industry experience, or a Master's in a related field.
• Strong understanding of downstream processing, experimental design, data analysis, and bioprocess development.

Responsibilities

• Serve as SME and technical lead for downstream purification of mAbs, recombinant proteins, and biologics.
• Lead chromatography screening, process optimization, and scale-up to support programs from development to manufacturing.
• Perform in-process and analytical testing (e.g., protein concentration, HPLC assays).
• Execute downstream unit operations using chromatography and filtration systems.
• Support process scale-up and technology transfer for pilot and GMP manufacturing.
• Compile data, write technical reports and client-facing documentation.
• Lead troubleshooting and continuous improvement to enhance process performance.
• Mentor junior scientists and contribute to evaluating new technologies.

Skills

Downstream processing

Chromatography

Process development

Scale-up

Data analysis

Mentoring

Troubleshooting

Documentation

Education

Bachelor's or Master’s in Chemical Engineering, Biochemical Engineering, Biotechnology or related field

Tools

HPLC

Filtration equipment

Process analytics tools

Job description

Senior Research Associate, Process Development Downstream

Location: Tustin, CA

Join a passionate team dedicated to developing and manufacturing life-saving biopharmaceuticals. We are seeking a Senior Research Associate to lead downstream process and/or method development in a dynamic laboratory environment.

Key Responsibilities:

• Serve as a subject matter expert and technical lead for downstream process development and purification of monoclonal antibodies, recombinant proteins, and related biologics, including buffer formulation, chromatography process development, filtration, and routine process execution.


• Lead downstream process development studies, including chromatography screening, process optimization, and scale-up activities to support programs from early development through commercialization.


• Perform and oversee in-process and routine analytical testing (e.g., protein concentration determination, HPLC-based assays).


• Independently execute downstream unit operations using chromatography systems, filtration equipment, and process analytical tools.


• Support process scale-up, technology transfer, and manufacturing operations by developing robust buffer preparation strategies and downstream processing workflows for pilot and GMP manufacturing.


• Compile, analyze, interpret, and present experimental data; author technical reports and client-facing documentation.


• Lead troubleshooting and continuous improvement initiatives to enhance process performance and scalability.


• Contribute to the evaluation and implementation of emerging technologies, process analytics, laboratory automation, and process intensification strategies.


• Mentor junior scientists and provide technical guidance.

Minimum Qualifications:

• Bachelor's degree with 3-4 years of relevant biopharmaceutical industry experience, or a Master's degree in Chemical Engineering, Biochemical Engineering, Biotechnology, Biological Sciences, or a related field.


• Strong understanding of downstream processing principles, experimental design, data analysis, and bioprocess development methodologies.

Additional Information:

• Full-time onsite position, Monday through Friday, with potential overtime or weekend work as needed.


• Competitive compensation ($72,800 - $91,000 annually), performance-based bonuses, and comprehensive benefits including health, dental, vision, 401(k) matching, and paid time off.


• Opportunities for career growth and a supportive, inclusive work environment.


• Physical demands include sitting, standing, walking, and occasional lifting (up to 25 lbs); reasonable accommodations available.


• Monday through Friday, full-time onsite; must be able to work overtime and/or weekends when necessary

Applicants must be legally authorized to work in the United States for any employer. Sponsorship is not available for this position now or in the future.