iPSC Microglia Therapy Scientist for Alzheimer’s

Retro Biosciences; Redwood City (CA); On-site; USD 150,000 - 190,000; Full time

Benefits offered by this job

Medical/Dental/Vision

401(k) with 4% matching

Flexible time off

Parental leave

Learning stipend

Longevity stipend

Lunch and snacks

Job summary

Retro Biosciences seeks an experienced, hands-on scientist to join the Microglia Therapeutics team and drive discovery research in Alzheimer’s disease. You will develop in vitro and in vivo models, establish assays, and interpret experiments to evaluate microglial cell therapy.

You will culture and differentiate iPSCs into CNS cell types, design 2D and 3D models, optimize in vivo disease models, and integrate findings across experiments to refine hypotheses.

Qualifications

• PhD in Neuroscience, Biology, or related field.
• At least 3 years of post-degree experience in academia or industry.
• Hands-on experience in Alzheimer’s disease research.
• Strong mammalian cell culture skills and iPSC-derived neural cells.

Responsibilities

• Design and execute discovery experiments for microglial cell therapy in Alzheimer’s disease.
• Culture and differentiate iPSCs into CNS cell types and optimize 2D/3D protocols.
• Develop 2D/3D in vitro disease models to study responses to Alzheimer’s challenges.
• Design and optimize in vivo modeling approaches, including models, controls, time points, and readouts.
• Develop cellular and molecular assays to evaluate microglial function and pathology readouts.
• Perform staining and fluorescence/confocal imaging on cells, organoids, and brain tissue.
• Collaborate with histology/imaging teams and integrate findings across studies.
• Analyze and present results to internal teams and collaborators.

Skills

Experiment design

2D & 3D models

In vivo modeling

Cell-based assays

Molecular assays

Imaging analysis

Data interpretation

Collaborative work

Education

PhD in Neuroscience/Biology

Tools

Immunostaining

Fluorescence microscopy

Confocal microscopy

iPSC-derived neural cells

Job description

Retro Biosciences seeks an experienced, hands-on scientist to join the Microglia Therapeutics team and drive discovery research in Alzheimer’s disease. You will develop in vitro and in vivo models, establish assays, and interpret experiments to evaluate microglial cell therapy.

You will culture and differentiate iPSCs into CNS cell types, design 2D and 3D models, optimize in vivo disease models, and integrate findings across experiments to refine hypotheses.