In Vitro Pharmacology Lead - Oligo Therapeutics

Saturnus Bio; Boston (MA); On-site; USD 120,000 - 160,000; Full time

Job summary

Saturnus Bio, a precision cardiology therapeutics company, seeks an in vitro pharmacologist to join our team and develop new oligonucleotide therapeutics for genetic cardiomyopathy populations. The successful candidate will excel in high-quality research and contribute on projects through early discovery.

You will design, develop, and execute assays to quantify RNA and protein modulation, collaborating with chemistry and translational teams to advance candidates from discovery through lead

Qualifications

• BA with 5+ years biotech/pharma lab experience or MA with 3+ years biotech/pharma lab experience.
• Expertise in RNA-targeting oligonucleotide therapeutics including ASO/siRNA screening.
• Experience with mammalian cell culture, transfection methods, and quantitative assays for nucleic acids and proteins.
• Ability to work independently with flexibility to adapt to company priorities.
• Time management and strong record-keeping with electronic notebooks.

Responsibilities

• Contribute to ASO/siRNA discovery programs from target evaluation to lead selection.
• Develop, optimize, and apply molecular, cellular, and biochemical assays to quantify RNA and protein modulation.
• Collaborate with chemistry, bioinformatics, and translational teams to advance oligonucleotide therapeutics.
• Maintain accurate experimental documentation and reports.
• Present results at cross-functional team meetings.

Skills

RNA targeting oligonucleotide

Mammalian cell culture

Transfection methods

Quantitative RNA/protein assays

Independent work

Electronic notebooks

Education

Bachelor's degree in biotech/pharma

Master's degree in biotech/pharma

Job description

Saturnus Bio, a precision cardiology therapeutics company, seeks an in vitro pharmacologist to join our team and develop new oligonucleotide therapeutics for genetic cardiomyopathy populations. The successful candidate will excel in high-quality research and contribute on projects through early discovery.

You will design, develop, and execute assays to quantify RNA and protein modulation, collaborating with chemistry and translational teams to advance candidates from discovery through lead