Hybrid Technical Program Lead, HTS Platform

Illumina, Inc.; San Diego (CA); Hybrid; USD 129,000 - 194,000; Full time

Job summary

Illumina, Inc. is seeking a Staff Program Manager to lead High Throughput Sequencing platform initiatives (NovaSeq X and NovaSeq 6000) and sustaining activities.

You will translate strategic priorities into executable plans, driving improvements in reliability, quality, and customer experience across cross-functional teams. In a highly matrixed environment, you will manage integrated schedules, budgets, risks, and governance reviews, communicating with executive leadership and stakeholders to

Qualifications

• Strong program management experience leading complex cross-functional technical initiatives in a highly matrixed environment.
• Ability to develop and manage integrated schedules, resource plans, budgets, and executive-level status reporting.
• Expertise in program governance, risk management, issue resolution, and stakeholder alignment.
• Experience with hardware, software, consumables, and/or integrated product systems.
• Knowledge of FDA-regulated product environments, design controls, risk management, and change management processes.
• Excellent communication, presentation, negotiation, and executive-influence skills.
• Familiarity with next-generation sequencing platforms, molecular biology, genomics, or life science instrumentation preferred.
• Experience supporting quality investigations, corrective actions, field actions, post-launch activities, or sustaining programs preferred.

Responsibilities

• Lead execution of High Throughput platform initiatives spanning product improvements, reliability enhancements, quality actions, lifecycle management activities, and business performance objectives.
• Partner with Product Technical Leads, Development, Quality, Operations, Service, Supply Chain, Regulatory, Marketing, and Commercial teams to define and execute platform priorities.
• Develop, maintain, and communicate integrated program plans, including scope, schedules, resource requirements, dependencies, risks, budgets, and milestones.
• Coordinate execution of On-Market Core Team (OMCT) activities, governance forums, and executive reviews to drive alignment, accountability, and decision-making.
• Drive cross-functional planning and prioritization for platform investments, sustaining activities, customer-driven improvements, and operational initiatives.
• Identify, manage, and communicate program risks, issues, dependencies, and trade-offs while facilitating escalation and resolution pathways.
• Track and report program performance, key milestones, and portfolio health metrics to functional and executive leadership.
• Support lifecycle management activities, including product enhancements, obsolescence planning, end-of-support readiness, serviceability improvements, and cost optimization initiatives.
• Lead execution planning for design changes, quality improvements, corrective actions, field issues, and post-market initiatives.
• Partner with finance and functional leaders on resource planning, capacity management, budget forecasting, and investment prioritization.
• Drive continuous improvement of governance, portfolio management, and program management processes to improve organizational effectiveness.
• Facilitate communication across stakeholders and ensure alignment between technical execution, customer needs, business objectives, and regulatory requirements.

Skills

Strong program management

Integrated schedules

Governance

Executive communication

Product lifecycle

Hardware/Software/Systems

FDA-regulated knowledge

Communication/negotiation

Genomics familiarity

Quality investigations knowledge

Education

Bachelor’s degree

Master’s degree

PhD

PMP certification

Job description

Illumina, Inc. is seeking a Staff Program Manager to lead High Throughput Sequencing platform initiatives (NovaSeq X and NovaSeq 6000) and sustaining activities.

You will translate strategic priorities into executable plans, driving improvements in reliability, quality, and customer experience across cross-functional teams. In a highly matrixed environment, you will manage integrated schedules, budgets, risks, and governance reviews, communicating with executive leadership and stakeholders to