Head of Quantitative Systems Pharmacology

GlaxoSmithKline; Waltham (MA); On-site; USD 188,000 - 314,000; Full time

Benefits offered by this job

Annual bonus

Health care

Long-term incentive program

Job summary

GSK’s CPQM unit in Respiratory, Immunology and Inflammation Research is recruiting a Quantitative Systems Pharmacologist Lead. Candidates with PhD, MD or PharmD and strong mechanistic modeling experience are encouraged to apply for a senior role shaping model-informed drug development.

The position offers a US-based base salary, bonus eligibility, extensive benefits, and relocation consideration, with locations including Cambridge, MA and Waltham, MA.

Qualifications

• PhD, MD, or PharmD with experience in mechanistic modelling and simulation and systems biology with applications in pharmaceutical research and development.
• Minimum 7 years of experience in mechanistic mathematical modeling, inverse problem modeling and simulation, and/or scientific machine learning methodologies to be applied to pre-clinical and/or clinical questions in drug development to solve practical problems in the pharmaceutical industry.
• Experience working with senior stakeholders in a cross functional environment.
• Track record of implementation of Model-Informed Drug Discovery and Development (MIDD) approaches to accelerate patient access to novel therapies and to expand therapeutic indications of marketed drugs.

Responsibilities

• Build and guide mathematical model development to understand disease, its progression, and drug action to prevent, treat and cure diseases; conduct simulations to assess trial design performance.
• Apply mechanistic models of biological, physiological, and pathophysiological processes to evaluate a disease, its pathways and progression, as well as drug candidates or treatment modalities.
• Define and execute a coordinated scientific and technical strategy with demonstrated ability to co-ordinate outputs from several expertise areas to determine strategy.
• Work in close collaboration with biologists, clinicians, clinical pharmacologists, pharmacometricians, statisticians, AIML, imaging, biomarker and other partner line colleagues to inform research and development programs and improve our understanding of disease mechanisms.
• Implement best practices, trends, lessons learned from internal and external sources to further clinical pharmacology modelling and simulation contributions to R&D pipeline.

Skills

Drug Design

Drug Development

Drug Discovery Process

Drug Discovery Research

Medication Safety

Molecular Modeling

Pharmaceutical Regulatory Compliance

Pharmaceutical Sciences

Pharmacodynamics

Pharmacokinetics

Pharmacology

Pharmacometrics

Pharmacovigilance

Study Design

Target Validation

Education

PhD, MD, or PharmD

Job description

GSK’s CPQM unit in Respiratory, Immunology and Inflammation Research is recruiting a Quantitative Systems Pharmacologist Lead. Candidates with PhD, MD or PharmD and strong mechanistic modeling experience are encouraged to apply for a senior role shaping model-informed drug development.

The position offers a US-based base salary, bonus eligibility, extensive benefits, and relocation consideration, with locations including Cambridge, MA and Waltham, MA.