Head of Pooled Screening Core — CAR & Cell Therapies

Johnson & Johnson Innovative Medicine; Spring House (PA); On-site; USD 180,000 - 240,000; Full time

Job summary

Johnson & Johnson Innovative Medicine in Spring House, PA seeks a Sr. Manager, Pooled Screening Core - CAR Screening & Lead Selection to establish and lead a centralized pooled screening core within Cell & Genetic Medicines. You will provide scientific and operational leadership from design through data delivery.

The role requires deep technical depth, people leadership, and a service-oriented approach to accelerate discovery and advance our cell therapy portfolio.

Qualifications

• PhD in molecular biology, cell biology, immunology, bioengineering, biotechnology, or a related discipline with substantial industry experience.
• Deep expertise in pooled screening technologies and ability to design, execute, troubleshoot, and interpret complex screening studies.
• Experience leading scientific or multidisciplinary technical teams, mentoring talent, and fostering a collaborative, service‑oriented culture.
• Proven ability to establish scalable workflows and operating practices, manage concurrent priorities, and maintain high standards for quality and delivery.
• Strong cross‑functional leadership and relationship-building skills with influence beyond formal authority.
• Excellent written and verbal communication skills.

Responsibilities

• Serve as CGM’s scientific lead and subject matter expert for pooled screening technologies, strategy, applications, and limitations.
• Develop, optimize, and implement scalable pooled screening workflows spanning library design, cloning, quality control, cell engineering, functional assays, sequencing readouts, and data interpretation.
• Build trusted relationships with project teams and translate scientific questions into rigorous study designs, controls, models, endpoints, and follow-up plans.
• Build strong cross-functional relationships and integrate pooled screening with existing arrayed screening, automation, CAR-T generation, vector, and assay development teams and capabilities.
• Establish and lead the Core’s operating model, including project intake, prioritization, resource planning, scheduling, execution, and data delivery, with transparent decision-making and clear, proactive stakeholder communication.
• Ensure high standards for scientific rigor, reproducibility, quality, documentation, sample tracking, biosafety, and knowledge management.
• Monitor and document Core performance through metrics for throughput, quality, turnaround time, utilization, and portfolio impact, and drive continuous improvement.
• Provide hands‑on scientific and operational oversight, troubleshoot complex studies, and balance competing priorities across concurrent requests.
• Lead, develop, and expand the Core team by setting clear expectations, mentoring scientists, and fostering a collaborative, service-oriented culture.
• Represent the Core in portfolio and platform discussions, communicate capacity, priorities, risks, and investment needs transparently, and serve as a trusted partner and primary point of contact for project and cross‑functional teams.

Skills

Pooled screening

People leadership

Cross-functional collaboration

Scientific strategy

Project management

Communication

Education

PhD in biosciences or related field

Job description

Johnson & Johnson Innovative Medicine in Spring House, PA seeks a Sr. Manager, Pooled Screening Core - CAR Screening & Lead Selection to establish and lead a centralized pooled screening core within Cell & Genetic Medicines. You will provide scientific and operational leadership from design through data delivery.

The role requires deep technical depth, people leadership, and a service-oriented approach to accelerate discovery and advance our cell therapy portfolio.