Lead, Pooled Screening Core — CAR & Gene Medicines

Johnson Johnson; Spring House (PA); On-site; USD 150,000 - 210,000; Full time

Job summary

Johnson & Johnson in Spring House, PA is seeking a Sr. Manager, Pooled Screening Core – CAR Screening & Lead Selection within Cell & Genetic Medicines.

The role leads a centralized pooled screening core, serving as people leader and scientific authority, guiding design, execution, and data delivery across screening workflows. You will build scalable, high-throughput capabilities and partner with project teams to translate questions into rigorous study designs, controls, and endpoints.

Responsibilities

• Serve as CGM's scientific lead and subject matter expert for pooled screening technologies, strategy, applications, and limitations.
• Develop, optimize, and implement scalable pooled screening workflows spanning library design, cloning, quality control, cell engineering, functional assays, sequencing readouts, and data interpretation.
• Build trusted relationships with project teams and translate scientific questions into rigorous study designs, controls, models, endpoints, and follow-up plans.
• Build strong cross-functional relationships and integrate pooled screening with existing arrayed screening, automation, CAR-T generation, vector, and assay development teams and capabilities.
• Establish and lead the Core's operating model, including project intake, prioritization, resource planning, scheduling, execution, and data delivery, with transparent decision-making and clear, proactive stakeholder communication.
• Ensure high standards for scientific rigor, reproducibility, quality, documentation, sample tracking, biosafety, and knowledge management.
• Monitor and document Core performance through metrics for throughput, quality, turnaround time, utilization, and portfolio impact, and drive continuous improvement.
• Provide hands-on scientific and operational oversight, troubleshoot complex studies, and balance competing priorities across concurrent requests.
• Lead, develop, and expand the Core team by setting clear expectations, mentoring scientists, and fostering a collabora

Job description

Johnson & Johnson in Spring House, PA is seeking a Sr. Manager, Pooled Screening Core – CAR Screening & Lead Selection within Cell & Genetic Medicines.

The role leads a centralized pooled screening core, serving as people leader and scientific authority, guiding design, execution, and data delivery across screening workflows. You will build scalable, high-throughput capabilities and partner with project teams to translate questions into rigorous study designs, controls, and endpoints.