Sr. Manager, Pooled Screening Core - CAR Screening & Lead Selection, Cell & Genetic Medicines

Johnson Johnson; Spring House (PA); On-site; USD 150,000 - 210,000; Full time

Job summary

Johnson & Johnson in Spring House, PA is seeking a Sr. Manager, Pooled Screening Core – CAR Screening & Lead Selection within Cell & Genetic Medicines.

The role leads a centralized pooled screening core, serving as people leader and scientific authority, guiding design, execution, and data delivery across screening workflows. You will build scalable, high-throughput capabilities and partner with project teams to translate questions into rigorous study designs, controls, and endpoints.

Responsibilities

• Serve as CGM's scientific lead and subject matter expert for pooled screening technologies, strategy, applications, and limitations.
• Develop, optimize, and implement scalable pooled screening workflows spanning library design, cloning, quality control, cell engineering, functional assays, sequencing readouts, and data interpretation.
• Build trusted relationships with project teams and translate scientific questions into rigorous study designs, controls, models, endpoints, and follow-up plans.
• Build strong cross-functional relationships and integrate pooled screening with existing arrayed screening, automation, CAR-T generation, vector, and assay development teams and capabilities.
• Establish and lead the Core's operating model, including project intake, prioritization, resource planning, scheduling, execution, and data delivery, with transparent decision-making and clear, proactive stakeholder communication.
• Ensure high standards for scientific rigor, reproducibility, quality, documentation, sample tracking, biosafety, and knowledge management.
• Monitor and document Core performance through metrics for throughput, quality, turnaround time, utilization, and portfolio impact, and drive continuous improvement.
• Provide hands-on scientific and operational oversight, troubleshoot complex studies, and balance competing priorities across concurrent requests.
• Lead, develop, and expand the Core team by setting clear expectations, mentoring scientists, and fostering a collabora

Job description

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com .

As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Biotherapeutics R&D

Job Category:

People Leader

All Job Posting Locations:

Spring House, Pennsylvania, United States of America

Job Description:

This job posting is anticipated to close on Oct 09 2026. We may however extend this time period, in which case the posting will remain available on www.careers.jnj.com to accept additional applications.

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

We are searching for the best talent for a Sr. Manager, Pooled Screening Core - CAR Screening & Lead Selection, Cell & Genetic Medicines to be located in Spring House, PA.

Purpose:

The CSLS team is seeking a Sr. Manager to establish and lead a centralized pooled screening core within the Cell & Genetic Medicines organization. This individual will serve as the people leader and operational supervisor of the Pooled Screening Core while providing scientific and technical leadership across pooled screening technologies and workflows.

The Pooled Screening Core will provide a service-oriented, high-throughput capability to interrogate large protein and genomic design spaces. It will complement existing arrayed screening capabilities and help project teams rapidly identify promising designs for further characterization and lead selection. The Core Lead will be responsible for building a scalable, reliable, and customer-focused capability spanning experimental design through data delivery.

This role requires a leader who can operate at the intersection of deep technical expertise, people leadership, operational excellence, and cross-functional scientific partnership. The successful candidate will establish standards and workflows for the Core; develop and mentor its scientists; partner with project teams to design, prioritize, and execute studies appropriately; and ensure that pooled screening capabilities evolve alongside the needs of the cell therapy portfolio.

This is an opportunity to shape a high-impact scientific capability from the ground up. The successful candidate will bring technical depth, operational discipline, and a collaborative leadership style to build a trusted Core that accelerates discovery, strengthens partnerships, and advances our cell therapy portfolio.

You will be responsible for:

• Serve as CGM's scientific lead and subject matter expert for pooled screening technologies, strategy, applications, and limitations.
• Develop, optimize, and implement scalable pooled screening workflows spanning library design, cloning, quality control, cell engineering, functional assays, sequencing readouts, and data interpretation.
• Build trusted relationships with project teams and translate scientific questions into rigorous study designs, controls, models, endpoints, and follow-up plans.
• Build strong cross-functional relationships and integrate pooled screening with existing arrayed screening, automation, CAR-T generation, vector, and assay development teams and capabilities.
• Establish and lead the Core's operating model, including project intake, prioritization, resource planning, scheduling, execution, and data delivery, with transparent decision-making and clear, proactive stakeholder communication.
• Ensure high standards for scientific rigor, reproducibility, quality, documentation, sample tracking, biosafety, and knowledge management.
• Monitor and document Core performance through metrics for throughput, quality, turnaround time, utilization, and portfolio impact, and drive continuous improvement.
• Provide hands-on scientific and operational oversight, troubleshoot complex studies, and balance competing priorities across concurrent requests.
• Lead, develop, and expand the Core team by setting clear expectations, mentoring scientists, and fostering a collaborati