Head Clinical Pharmacology and Pharmacometrics (Executive Director - Vice President)

Merus; Cambridge (MA); On-site; USD 120,000 - 250,000; Full time

Job summary

Join a forward-thinking company dedicated to advancing targeted cancer treatments. As the Head of Clinical Pharmacology and Pharmacometrics, you'll lead a talented team in driving innovative solutions and strategic direction. This role offers the chance to collaborate with experts in the biotech field and significantly impact patients' lives. With a commitment to excellence and a supportive environment, you'll be empowered to contribute to groundbreaking projects that matter. If you're passionate about making a difference in oncology and have the required expertise, this opportunity is perfect for you.

Benefits

Highly competitive total rewards package

Tailored training and development

Career opportunities matching ambitions

Collaborative international team environment

Qualifications

• Ph.D. with 15+ years in industry, focusing on translational pharmacology.
• Experience with monoclonal antibodies and ADCs preferred.

Responsibilities

• Lead Translational Pharmacology and Pharmacometrics functions.
• Collaborate with teams to enhance product lifecycle decision-making.

Skills

Quantitative Approaches

Leadership Skills

Pharmacokinetics/Pharmacodynamics (PKPD)

Modeling and Simulation

Oncology Expertise

Education

Ph.D. or equivalent degree

Tools

Mechanistic Modeling

Biologics License Application (BLA)

Job description

Head Clinical Pharmacology and Pharmacometrics (Executive Director - Vice President)

Application Deadline: 28 May 2025

Department: Clinical Development

Employment Type: Full Time

Location: Cambridge, MA

Description

Company Overview
At Merus, we are advancing leading-edge, targeted treatments using our pioneering multispecific antibody generating technologies, Multiclonics, to address the unmet needs of patients with various types of cancer. Working at Merus gives you the opportunity to contribute to our mission of closing in on cancer. We care deeply about improving patients' lives. This is why we are committed to getting this right, with a global and diverse team of highly qualified professionals. We have bold aspirations because the need is great, and the patients are waiting. Join us and make an impact.

Your role:
Merus is seeking a Head of Clinical Pharmacology and Pharmacometrics to serve as the functional leader of the Translational Pharmacology, Clinical Pharmacology, and Pharmacometrics functions of the company. This position will be reporting to the VP of Clinical and Bioanalytical Sciences.

In this role you will:

1. Serve as the functional leader of the Translational Pharmacology, Clinical Pharmacology, and Pharmacometrics functions of the company.
2. Be accountable for managing people, set the strategic direction of the group, and allocate resources.
3. Collaborate with other functions to integrate quantitative approaches throughout the product lifecycle, enhancing technical success and decision-making confidence.
4. Partner with early research to provide foundational insights for optimization of key molecular attributes of mAbs and ADCs to inform prioritization from product concept to preclinical optimization.
5. Collaborate closely with clinical stage project teams to provide scientific insights that drive clinical development decisions and support regulatory submissions.

Your profile:
We are looking for a candidate with:

1. Ph.D. or equivalent degree with at least 15 years of industry experience.
2. Educational background in PKPD, pharmacometrics, chemical engineering, biomedical engineering, biostatistics, or mathematics.
3. Prior experience working with monoclonal and multispecific antibodies; experience with ADCs is preferred.
4. Demonstrated strong technical expertise in quantitative approaches to translational pharmacology, early research, and clinical development.
5. Prior experience in using semi-/mechanistic modeling for target selection, target product profile optimization, and compound prioritization in early research.
6. Track record in using modeling and simulation approaches to support regulatory discussions and Biologics License Application (BLA) submissions.
7. Experience in Oncology.
8. Strong leadership skills with the ability to effectively influence cross-functional teams.
9. Strong work ethic, commitment to excellence, and openness to new ideas and feedback.

Our offer
We offer an exciting opportunity to work with some of the best and brightest in the biotech industry. As part of Merus, you'll have the chance to collaborate with an exceptional international team of people who are passionate about what they do. To top it off, we offer a highly competitive total rewards package (benefits and compensation), training that is tailored to your individual development, and career opportunities that match your ambitions. Most importantly, you'll have the chance to help us close in on cancer - everything you do matters at Merus.