Formulation Scientist I - Lipid Nanoparticles

TALENT Software Services; San Diego (CA); On-site; USD 90,000 - 130,000; Full time

Job summary

TALENT Software Services in San Diego, CA, seeks a Scientist 1 to join the Formulation team, focusing on lipid nanoparticle (LNP) formulation and encapsulation of nucleic acids for in vitro and in vivo studies.

This hands-on role collaborates with senior scientists to execute and optimize LNPs, perform DoE-based screening, document results, and support early-stage formulation development and downstream processing as needed. Strong analytical skills and attention to detail are essential.

Qualifications

• Bachelor's degree in Chemistry, Biochemistry, Chemical Engineering, or a related discipline with 4+ years of biopharma industry experience, OR a Master's degree with 1+ years of industry experience.
• Minimum of 2 years hands-on laboratory experience specializing in LNP formulation and encapsulation of nucleic acids (mRNA, siRNA, or DNA).
• Proficiency with standard LNP characterization methods, including DLS, Zeta potential, and Ribogreen assays.
• High proficiency in MS Excel; experience with JMP or Prism preferred.

Responsibilities

• Execute and optimize the formulation and characterization of LNPs or tLNPs encapsulating nucleic acids for in vitro and in vivo studies.
• Implement DoE-based screening campaigns to evaluate and establish optimal LNP compositions and processing parameters.
• Collaborate cross-functionally with internal teams to support formulation requests.
• Support early-stage formulation development and downstream processing activities, including cryoprotection, scale-up, and stability studies.
• Maintain detailed records documenting formulation activities and results.
• Analyze, interpret, and present experimental data to the formulation team.
• Contribute to routine lab management activities, including inventory tracking and buffer preparation.

Skills

LNP formulation

Analytical skills

Excel proficiency

Data analysis software

Attention to detail

Team collaboration

Education

Bachelor's degree in Chemistry, Biochemistry, Chemical Engineering, or related discipline

Master's degree with 1+ years industry experience

Tools

DLS

Zeta potential

Ribogreen assay

Job description

TALENT Software Services in San Diego, CA, seeks a Scientist 1 to join the Formulation team, focusing on lipid nanoparticle (LNP) formulation and encapsulation of nucleic acids for in vitro and in vivo studies.

This hands-on role collaborates with senior scientists to execute and optimize LNPs, perform DoE-based screening, document results, and support early-stage formulation development and downstream processing as needed. Strong analytical skills and attention to detail are essential.