LNP Drug Product Scientist – Formulation & Purification

Quiet Capital; South San Francisco (CA); On-site; USD 113,000 - 171,000; Full time

Benefits offered by this job

Health insurance

401(k) with company match

Paid parental leave

Industry-leading PTO

On-site meals and snacks

Job summary

NewLimit is seeking a Scientist to join our Delivery Sciences team in South San Francisco. You will develop formulations, purification processes, and characterization methods for lipid nanoparticle (LNP) drug products used to carry reprogramming payloads to target cells.

The ideal candidate has deep expertise in LNP assembly, downstream purification, and analytical characterization, and will interpret complex data, maintain ELN records, and collaborate with Epigenetic Editing and Product teams

Qualifications

• Ph.D. in Biomedical Engineering, Chemical Biology, Pharmaceutical Sciences, or related discipline or equivalent industry experience.
• Experience formulating LNPs with diverse lipid components for nucleic acid delivery.
• Experience with purification techniques (dialysis, TFF, ultracentrifugation, sterile filtration).
• Proficiency in LNP analysis using dynamic or multi-angle light scattering, LC and standard molecular biology assays.

Responsibilities

• Formulate, purify, and characterize LNPs for nucleic acid delivery.
• Collaborate with Epigenetic Editing and Product teams to develop LNP‑RNA reprogramming medicines.
• Develop and optimize LNP compositions to target new cell types for reprogramming.
• Interpret complex experimental data and perform statistical analyses to reach robust conclusions.
• Maintain rigorous and detailed records of experimental protocols and results in an ELN.

Skills

Statistical analysis

Data interpretation

Collaboration

Education

Ph.D. in Biomedical Engineering, Chemical Biology, Pharmaceutical Sciences, or related discipline

Tools

Dialysis

Tangential Flow Filtration (TFF)

Ultracentrifugation

Sterile filtration

Dynamic light scattering (DLS)

Multi-angle light scattering (MALS)

LC/LC instrumentation

Job description

NewLimit is seeking a Scientist to join our Delivery Sciences team in South San Francisco. You will develop formulations, purification processes, and characterization methods for lipid nanoparticle (LNP) drug products used to carry reprogramming payloads to target cells.

The ideal candidate has deep expertise in LNP assembly, downstream purification, and analytical characterization, and will interpret complex data, maintain ELN records, and collaborate with Epigenetic Editing and Product teams