Scientist I

TALENT Software Services; San Diego (CA); On-site; USD 90,000 - 130,000; Full time

Job summary

TALENT Software Services in San Diego, CA, seeks a Scientist 1 to join the Formulation team, focusing on lipid nanoparticle (LNP) formulation and encapsulation of nucleic acids for in vitro and in vivo studies.

This hands-on role collaborates with senior scientists to execute and optimize LNPs, perform DoE-based screening, document results, and support early-stage formulation development and downstream processing as needed. Strong analytical skills and attention to detail are essential.

Qualifications

• Bachelor's degree in Chemistry, Biochemistry, Chemical Engineering, or a related discipline with 4+ years of biopharma industry experience, OR a Master's degree with 1+ years of industry experience.
• Minimum of 2 years hands-on laboratory experience specializing in LNP formulation and encapsulation of nucleic acids (mRNA, siRNA, or DNA).
• Proficiency with standard LNP characterization methods, including DLS, Zeta potential, and Ribogreen assays.
• High proficiency in MS Excel; experience with JMP or Prism preferred.

Responsibilities

• Execute and optimize the formulation and characterization of LNPs or tLNPs encapsulating nucleic acids for in vitro and in vivo studies.
• Implement DoE-based screening campaigns to evaluate and establish optimal LNP compositions and processing parameters.
• Collaborate cross-functionally with internal teams to support formulation requests.
• Support early-stage formulation development and downstream processing activities, including cryoprotection, scale-up, and stability studies.
• Maintain detailed records documenting formulation activities and results.
• Analyze, interpret, and present experimental data to the formulation team.
• Contribute to routine lab management activities, including inventory tracking and buffer preparation.

Skills

LNP formulation

Analytical skills

Excel proficiency

Data analysis software

Attention to detail

Team collaboration

Education

Bachelor's degree in Chemistry, Biochemistry, Chemical Engineering, or related discipline

Master's degree with 1+ years industry experience

Tools

DLS

Zeta potential

Ribogreen assay

Job description

Onsite: San Diego, CA. No relocations.

Max Client Bill Rate: ***

Position Summary

We are seeking a motivated and detail-oriented Scientist 1 to join our Formulation team. In this hands-on laboratory role, you will work closely with senior scientists to execute and optimize the synthesis of targeted and non-targeted lipid nanoparticles (LNPs) for nucleic acid delivery. The successful candidate will be a collaborative team player with strong technical and data analysis skills who is ready to contribute to our non-viral delivery platform.

Responsibilities

• Execute and optimize the formulation and characterization of lipid nanoparticles (LNPs) or targeted lipid nanoparticle (tLNPs) encapsulating nucleic acids for in vitro and in vivo studies under the minor guidance of senior formulation scientists.
• Implement Design of Experiment (DoE) based screening campaigns to evaluate and establish optimal LNP compositions and processing parameters.
• Collaborate cross-functionally with internal teams to support and fulfill formulation requests.
• Support early-stage formulation development and downstream processing activities when needed, including cryoprotection, scale-up, and stability studies.
• Maintain detailed records documenting formulation activities and results.
• Analyze, interpret, and present experimental data to the formulation team.
• Contribute to routine lab management activities, including inventory tracking, supply ordering, buffer preparation, and autoclaving.

Requirements, Knowledge, Skills, and Abilities

• Education: Bachelor's degree in Chemistry, Biochemistry, Chemical Engineering, or a related discipline with 4+ years of biopharma industry experience, OR a Master's degree with 1+ years of industry experience.
• LNP Expertise: Minimum of 2 years of hands-on laboratory experience specializing in LNP formulation and encapsulation of nucleic acids (mRNA, siRNA, or DNA).
• Analytical Skills: Proficiency with standard LNP characterization methods, including Dynamic Light Scattering (DLS), Zeta potential, and Ribogreen assays.
• Software & Data: High proficiency in MS Excel is required; hands-on experience with statistical and data analysis software (e.g., JMP, Prism) is preferred.
• Core Competencies: Strong attention to detail, a track record of producing reproducible data, excellent organizational skills, and the ability to communicate effectively within a fast-paced team environment.
• Preferred Skills: Prior experience with targeted LNP preparation (mAb, Fab, ScFv, VHH coated LNP) and immune cell delivery is highly desirable.