Expert Science and Technology - Gene Therapy Analytical Development - Chemistry

Biopharma Careers; East Hanover (NJ); On-site; USD 104,000 - 192,000; Full time

Job summary

Novartis in East Hanover, NJ is seeking a Gene Therapy Analytical Development Chemist who will independently design, execute, and report analytical studies to support gene therapy product development. You will characterize product quality attributes and develop and transfer analytical methods for characterization, process development, and stability assessment.

The role requires solving analytical challenges, mentoring junior scientists, and ensuring GMP and data integrity.

Qualifications

• PhD with 3+ years in industry or MS with 4+ years or BS with 5+ years.
• Strong foundation in analytical chemistry and related disciplines.
• Experience with biologics, viral vectors, or gene therapy analytics.
• Hands-on experience with listed analytical platforms.
• Experience with GMP documentation preferred; experience with AAV/lentiviral vectors preferred.

Responsibilities

• Design, execute, analyze, and report analytical studies for gene therapy programs.
• Develop, qualify, transfer, and optimize analytical methods for characterization and stability.
• Troubleshoot analytical challenges and provide data-driven solutions.
• Perform characterization using chromatography, CE, and biophysical techniques.
• Contribute expertise to cross-functional teams and communicate findings.
• Author and review technical reports, SOPs, and regulatory documents.
• Evaluate emerging technologies and improve analytical capabilities.
• Mentor junior scientists and foster a collaborative environment.
• Ensure GMP compliance and data integrity.

Skills

Analytical chemistry

Protein chemistry

Nucleic acid chemistry

HPLC/UPLC

Mass spectrometry

Education

PhD in Chemistry, Biochemistry, Pharmaceutical Sciences

MS in related field

BS in related field

Tools

HPLC/UPLC

CE-SDS

icIEF

SEC-MALS

Mass spectrometry

Job description

Location: East Hanover, US #onsite Relocation Support: This role is based in East Hanover, NJ, United States. Novartis is unable to offer relocation support: please only apply if accessible. Role Purpose: As a key member of the Gene Therapy Analytical Development Chemistry (AD-Chem) team, the successful candidate will independently design, execute, interpret, and communicate complex analytical studies supporting gene therapy product development. The individual will apply scientific expertise to characterize product quality attributes, develop and optimize analytical methods, solve analytical challenges, and generate data that advances development programs. The role serves as a key technical contributor within multidisciplinary project teams and supports innovation in gene therapy analytics.

What You Will Be Doing

• Independently design, execute, analyze, and report analytical studies supporting gene therapy development programs.
• Develop, optimize, qualify, and transfer analytical methods for product characterization, process development, and stability assessment.
• Apply scientific expertise to troubleshoot analytical challenges and provide data-driven solutions.
• Perform characterization studies using chromatography(LC), capillary electrophoresis(CE), and biophysical analytical techniques.
• Contribute analytical expertise to cross-functional project teams and effectively communicate scientific findings and recommendations.
• Author and review technical reports, qualification documents, SOPs, and regulatory-supporting documentation.
• Evaluate emerging technologies and contribute to continuous improvement of analytical capabilities.
• Mentor junior scientists and foster a collaborative, innovative, and quality-focused work environment.
• Ensure compliance with GMP, data integrity requirements, and Novartis quality standards.

What You Will Bring to the Role

• Ph.D. in Chemistry, Biochemistry, Pharmaceutical Sciences, or related discipline with 3+ years of relevant industry experience; OR MS with 4+ years; OR BS with 5+ years.
• Strong scientific foundation in analytical chemistry, protein chemistry, nucleic acid chemistry, or related disciplines.
• Experience with analytical characterization of biologics, viral vectors, or gene therapy products.
• Hands-on experience with one or more analytical platforms such as HPLC/UPLC, CE-SDS, icIEF, SEC-MALS, AUC, mass spectrometry, or particle characterization techniques.
• Demonstrated ability to independently design studies, analyze complex datasets, and solve technical challenges.
• Strong technical writing, communication, and presentation skills.
• Experience with analytical method qualification, transfer, validation, and GMP documentation is preferred.
• Experience supporting AAV and/or lentiviral vector development programs is preferred.

The salary for this position is expected to range between $103,600 and $192,400 per year. The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors.

Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards.

US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves.