Expert Science and Technology - Gene Therapy Analytical Development - Chemistry

Novartis; East Hanover (NJ); On-site; USD 104,000 - 192,000; Full time

Job summary

Novartis is seeking a senior analytical scientist to design and execute studies for gene therapy product development. The role emphasizes method development, qualification, and transfer across cross-functional teams, with emphasis on data integrity and regulatory documentation.

The candidate will mentor junior scientists, evaluate emerging technologies, and ensure compliance with GMP standards in a fast-paced environment in East Hanover, NJ. Competitive compensation and benefits apply.

Qualifications

• Ph.D. in Chemistry, Biochemistry, Pharmaceutical Sciences, or related discipline with 3+ years of relevant industry experience; OR MS with 4+ years; OR BS with 5+ years.
• Strong foundation in analytical chemistry, protein chemistry, nucleic acid chemistry, or related disciplines.
• Experience with analytical characterization of biologics, viral vectors, or gene therapy products.
• Hands-on experience with analytical platforms such as HPLC/UPLC, CE-SDS, icIEF, SEC-MALS, AUC, MS, or particle characterization.
• Demonstrated ability to design studies, analyze datasets, and solve technical challenges.

Responsibilities

• Independently design, execute, analyze, and report analytical studies supporting gene therapy development programs.
• Develop, qualify, transfer, and document analytical methods for product characterization, process development, and stability assessment.
• Troubleshoot analytical challenges and provide data-driven solutions.
• Perform characterization studies using chromatography, capillary electrophoresis, and biophysical techniques.
• Contribute analytical expertise to cross-functional teams and communicate findings.
• Author and review technical reports, qualification documents, SOPs, and regulatory documentation.
• Evaluate emerging technologies and drive continuous improvement of analytical capabilities.
• Mentor junior scientists and uphold GMP and data integrity.

Skills

Analytical chemistry

Protein chemistry

Nucleic acid chemistry

Biologics analysis

HPLC/UPLC

CE-SDS

icIEF

SEC-MALS

Education

PhD in Chemistry/Biochemistry/Pharmaceutical Sciences

MS in related field

BS in related field

Tools

HPLC/UPLC

CE-SDS

icIEF

SEC-MALS

AUC

Mass spectrometry

Particle characterization

Job description

Summary

Location: East Hanover, US #onsite
Relocation Support: This role is based in East Hanover, NJ, United States. Novartis is unable to offer relocation support: please only apply if accessible.

Role Purpose

As a key member of the Gene Therapy Analytical Development Chemistry (AD-Chem) team, the successful candidate will independently design, execute, interpret, and communicate complex analytical studies supporting gene therapy product development. The individual will apply scientific expertise to characterize product quality attributes, develop and optimize analytical methods, solve analytical challenges, and generate data that advances development programs. The role serves as a key technical contributor within multidisciplinary project teams and supports innovation in gene therapy analytics.

What You Will Be Doing

• Independently design, execute, analyze, and report analytical studies supporting gene therapy development programs.
• Develop, optimize, qualify, and transfer analytical methods for product characterization, process development, and stability assessment.
• Apply scientific expertise to troubleshoot analytical challenges and provide data-driven solutions.
• Perform characterization studies using chromatography(LC), capillary electrophoresis(CE), and biophysical analytical techniques.
• Contribute analytical expertise to cross-functional project teams and effectively communicate scientific findings and recommendations.
• Author and review technical reports, qualification documents, SOPs, and regulatory-supporting documentation.
• Evaluate emerging technologies and contribute to continuous improvement of analytical capabilities.
• Mentor junior scientists and foster a collaborative, innovative, and quality-focused work environment.
• Ensure compliance with GMP, data integrity requirements, and Novartis quality standards.

What You Will Bring To The Role

• Ph.D. in Chemistry, Biochemistry, Pharmaceutical Sciences, or related discipline with 3+ years of relevant industry experience; OR MS with 4+ years; OR BS with 5+ years.
• Strong scientific foundation in analytical chemistry, protein chemistry, nucleic acid chemistry, or related disciplines.
• Experience with analytical characterization of biologics, viral vectors, or gene therapy products.
• Hands-on experience with one or more analytical platforms such as HPLC/UPLC, CE-SDS, icIEF, SEC-MALS, AUC, mass spectrometry, or particle characterization techniques.
• Demonstrated ability to independently design studies, analyze complex datasets, and solve technical challenges.
• Strong technical writing, communication, and presentation skills.
• Experience with analytical method qualification, transfer, validation, and GMP documentation is preferred.
• Experience supporting AAV and/or lentiviral vector development programs is preferred.

The salary for this position is expected to range between $103,600 and $192,400 per year. The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors.

Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards.

US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves.

Why Novartis:

Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture

Benefits and Rewards:

Learn about all the ways we’ll help you thrive personally and professionally.

Read our handbook (PDF 30 MB)

EEO Statement

The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status.

Accessibility & Reasonable Accommodations

The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to [email protected] or call [phone] and let us know the nature of your request and your contact information. Please include the job requisition number in your message.