Director, GDC Head of ADC Oncology Chemistry

U175 (FCRS = US175) Novartis Institutes for BioMedical Research, Inc.; Cambridge (MA); On-site; USD 186,000 - 345,000; Full time

Benefits offered by this job

Flexible and hybrid working options

Minimum 14 weeks parental leave

Competitive benefits

Job summary

Novartis Institutes for BioMedical Research, Inc. in Cambridge, USA, is seeking a Director, Head of Antibody-Drug Conjugate Oncology Chemistry to lead our ADC portfolio from early discovery through key development milestones.

This leadership role sits at the intersection of chemistry, biology and drug discovery and emphasizes portfolio strategy and strong partnerships across disciplines. The role requires a doctoral degree, 12+ years in pharma/biotech R&D with proven oncology drug discovery

Qualifications

• Doctoral degree in Organic Chemistry, Medicinal Chemistry or closely related discipline.
• Minimum 12 years of pharma/biotech R&D, with significant leadership experience.
• Proven success advancing oncology drug discovery toward clinical development.

Responsibilities

• Lead medicinal chemistry strategy for antibody-drug conjugate programs across the oncology portfolio.
• Guide project teams from exploratory research to candidate nomination.
• Build, mentor and develop a high-performing medicinal chemistry team.
• Partner with biology, biotherapeutics, PK, safety and process chemistry to advance programs.
• Shape portfolio strategy, prioritization and resourcing in line with oncology goals.

Skills

Leadership

Cross-functional collaboration

Strategic planning

Team development

Education

Doctoral degree in Organic Chemistry

Tools

Computational chemistry tools

Structure-based drug design

Job description

Job Title

Director, Head of Antibody-Drug Conjugate Oncology Chemistry #LI-Onsite

Location

Cambridge, USA

Relocation Support

Yes

Job Description

You have the opportunity to shape the chemistry strategy behind the next generation of targeted oncology therapeutics. In this highly influential scientific leadership role, you will lead a talented team of medicinal chemists advancing antibody-drug conjugate and other vectorized drug conjugate programs from early discovery toward key development milestones. Working at the intersection of chemistry, biology and drug discovery, you will help shape portfolio strategy, guide innovative science and build strong partnerships across disciplines, while developing people and creating an environment where bold ideas can translate into meaningful treatments for patients.

Key Responsibilities

• Lead medicinal chemistry strategy for antibody-drug conjugate and vectorized drug conjugate programs across the oncology portfolio.
• Guide project teams toward critical drug discovery milestones, from exploratory research through candidate nomination.
• Build, mentor and develop a high-performing team of medicinal chemists across career levels.
• Partner across biology, biotherapeutics, pharmacokinetics, safety, and process chemistry to advance innovative therapeutic programs.
• Shape portfolio strategy, prioritization and resourcing decisions in alignment with broader oncology goals.
• Identify emerging technologies, external collaborations and scientific opportunities that strengthen the discovery portfolio.
• Foster an innovative, inclusive and collaborative environment while navigating complexity, ambiguity and organizational change.

Essential Requirements

• Doctoral degree in Organic Chemistry, Medicinal Chemistry or a closely related scientific discipline.
• Minimum 12 years of pharmaceutical or biotechnology research and development experience, including significant scientific and people leadership experience.
• Proven success advancing oncology drug discovery programs toward clinical development.
• Deep knowledge and experience with antibody-drug conjugates and other vectorized drug conjugate approaches.
• Broad understanding of drug discovery disciplines, including pharmacokinetics, toxicology and pharmacology.
• Demonstrated ability to lead multidisciplinary teams, influence across functions and translate complex science into strategic decisions.

Desirable Requirements

• Experience with computational chemistry tools and structure-based drug design.
• Deep expertise in synthetic organic chemistry, medicinal chemistry, structure-activity relationships, lead optimization and rational drug design.

Rewards

At Novartis, we’re committed to reimagining medicine together - and rewarding the people who make it happen. The rewards of being part of our team go far beyond base pay and incentives.

We also offer a variety of competitive benefits in kind to help you thrive personally and professionally, such as insurance plans, retirement plans, wellbeing resources and global recognition programs.

In addition, we provide flexible and hybrid working options, where possible, and a minimum of 14 weeks paid parental leave.

Expected Annual Base Salary Range for role: US: 185,500.00 - 344,500.00 USD Annual

The salary offered is determined based on gender-neutral objectives, such as relevant skills, competencies and experience in accordance with the Novartis pay setting policy and upon joining Novartis will be reviewed periodically. In addition to your base salary, you may be eligible for a performance-based bonus depending on certain performance parameters. Further details will be provided during the application process.

Pay equity is a fundamental principle of our employment policy and reflects our commitment to create a diverse, equitable and inclusive environment that treats all employees with dignity and respect, as outlined in our Code of Ethics.

Read our brochure to learn more about our global total rewards offering: https://www.novartis.com/sites/novartis_com/files/novartis-life-handbook.pdf

Note: Benefits and compensation may vary by country and are subject to local legal requirements, including provisions of collective bargaining agreements where applicable. A full overview of your compensation package, including any relevant collective bargaining agreement details applicable to your role based on your employment location and Novartis employer entity, will be communicated separately to you during the application process.

Why Novartis

Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture

Benefits and Rewards

Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

EEO Statement

The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status.

Accessibility and Reasonable Accommodations

The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to [e-mail] or call [phone] and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

Salary Range $185,500.00 - $344,500.00

Skills Desired Analytical Chemistry, Analytical Chemistry, Budget Control, Budget Management, Business Acumen, Chemical Analysis, Chemical Laboratory, Chemical Synthesis, Chemistry, Creativity, Curious Mindset, Data Analysis, Drug Development, Employee Development, Innovation, Inspirational Leadership, Medicinal Chemistry, Organic Chemistry, Pharmaceutical Industry, Project Team Management, R&D Management, Resource Allocation, Results-Oriented, Science, Strategic Planning {+ 1 more} Improving the lives of people living with disease takes more than innovative science. It takes a focus on the needs of people and a community committed to meeting them. It takes a team of people like you. Working together. Learning together. Thriving together. Discover how you can join us in changing people’s lives.