Senior Protein Engineer: AI‑Enabled, Structure‑Guided Design

Rippling, Inc.; Cambridge (MA); On-site; USD 135,000 - 150,000; Full time

Job summary

Arbor Biotechnologies, a clinical-stage gene editing company in Cambridge, MA, seeks a Senior Scientist to drive protein engineering workstreams for genome editing tools. You will design experiments, select mutants, and test variants in cellular and biochemical screens, with results shared across teams.

The role combines hands-on experimentation with data analysis and collaboration to advance best-in-class molecules. Experience with AI design tools for protein engineering is a plus.

Qualifications

• PhD in biology, biochemistry, molecular biology, bioengineering, or related discipline is required.
• 2+ years of related experience beyond PhD in relevant protein engineering fields.
• Hands-on experience with molecular biology, biochemistry, or cellular approaches to measure protein, enzyme, or editing activity.

Responsibilities

• Drive protein engineering workstreams, designing and evaluating protein mutants and variants.
• Collaborate with leads and cross-functional teams on experimental design and follow-up studies.
• Apply structure-guided and AI-assisted design approaches to prioritize variants and inform next steps.

Skills

Molecular biology techniques

Biochemistry

Data analysis

Protein engineering

CRISPR knowledge

Education

PhD in biology or related field

Tools

AAV production

mRNA generation

Illumina sequencing workflows

Job description

Arbor Biotechnologies, a clinical-stage gene editing company in Cambridge, MA, seeks a Senior Scientist to drive protein engineering workstreams for genome editing tools. You will design experiments, select mutants, and test variants in cellular and biochemical screens, with results shared across teams.

The role combines hands-on experimentation with data analysis and collaboration to advance best-in-class molecules. Experience with AI design tools for protein engineering is a plus.