Director, Site and CMC Program Management

Bristol-Myers Squibb; United States; On-site; USD 180,000 - 230,000; Full time

Job summary

RayzeBio, a wholly-owned subsidiary of Bristol Myers Squibb, seeks a Director of Program Management to provide strategic leadership and operational oversight for Indianapolis site-based CMC programs.

Work with Product Development, Operations, and external partners to deliver end-to-end programs, drive governance, and mature PM capabilities across the portfolio. This is a senior, cross-functional leadership role impacting patient outcomes.

Qualifications

• Strategic, execution-focused leader able to translate portfolio priorities into actionable plans and measurable outcomes.
• Strong understanding of drug development, CMC, manufacturing, supply chain, quality, regulatory, and/or radiopharmaceutical environments.
• Proven ability to influence senior leaders and align cross-functional teams without direct authority.

Responsibilities

• Drive strategic priorities on the Indianapolis site and align with Product Development and Operations leadership.
• Build and lead the Program Management team, governance routines, and KPIs to drive execution.
• Ensure CMC portfolio delivery across global product teams, processes, supply chain, production, quality, regulatory, and external partners.
• Translate strategic priorities into integrated plans, timelines, decisions, risk mitigation, and reporting.
• Lead prioritization and escalation discussions to align resources and maintain patient-impact focus.
• Coordinate site and portfolio initiatives, including manufacturing readiness, technology transfer, and supply chain planning.
• Identify risks, dependencies, and execution barriers; drive mitigation and escalation.
• Foster governance forums with clear agendas, actions, owners, and follow-through.
• Recruit, develop, and manage program management talent; define standards, tools, and ways of working.
• Strengthen program management maturity with critical path analysis, scenario planning, and executive communication.

Skills

Strategic leadership

Cross-functional influence

Program management

Education

Bachelor's degree in life sciences, chemistry, engineering, pharmaceutical sciences, business, or related discipline

Minimum 10 years in pharmaceutical/biotech with PM/CMC

Experience leading cross-functional teams

Job description

At RayzeBio, every day is an opportunity to ignite meaningful change. As a wholly-owned subsidiary of Bristol Myers Squibb, RayzeBio blends the nimble, pioneering spirit of an emergent biotech with the global expertise and resources of a leading innovator in oncology. Our mission is to develop transformative radiopharmaceutical therapies that offer new hope for patients living with cancer. Here, you'll join a multidisciplinary team where your ideas are valued, your expertise is amplified, and collaboration is at the heart of everything we do. From day one, expect to make an immediate impact-on our science, on our teams, and most importantly, on patients. Learn more about RayzeBio: https://careers.bms.com/rayzebio/

Position Summary

The Director, Program Management will provide strategic leadership and operational oversight for Indianapolis site-based and end-to-end CMC programs. This role will serve on the site leadership team, partner with Product Development and Operations leadership, build core program management capabilities, and ensure effective portfolio delivery across process development, supply chain, production, and related functions.

Job Responsibilities

Program Management Strategic Leadership

Serve on the Indianapolis site leadership team to drive strategic priorities and ensure alignment with Product Development and Operations leadership.

Build and lead the Program Management team, including planning capabilities, systems, processes, governance routines, and KPIs to drive execution.

Ensure CMC portfolio delivery by partnering across global product teams, key functions--process development, supply chain, production, quality, regulatory, engineering, and external partners.

Translate strategic priorities into integrated plans, timelines, decision points, risk mitigation strategies, and performance reporting.

Lead prioritization and escalation discussions to align resources, resolve barriers, and maintain focus on business and patient-impact priorities.

End-to-End CMC and Site Program Execution

Manage integrated CMC program planning and execution across site operations, global program teams, Product Development functions, Quality, Regulatory, Finance, and Commercial stakeholders.

Coordinate key site and portfolio initiatives, including manufacturing readiness, technology transfer, supply chain planning, engineering projects, CAPA related initiatives, and operational readiness.

Identify critical path risks, dependencies, resource constraints, and execution barriers; drive mitigation planning and timely escalation.

Facilitate effective governance forums with clear agendas, decisions, actions, owners, and follow-through.

Team and Capability Building

Recruit, develop, and manage program management talent to support evolving CMC and site priorities.

Define PM accountabilities, decision rights, escalation pathways, standards, tools templates, and ways of working.

Strengthen program management maturity through critical path analysis, scenario planning, executive communication, governance preparation, and performance tracking.

Foster a culture of accountability, collaboration, risk management, continuous improvement, and clear communication.

Communication, Governance, and Stakeholder Management

Prepare concice updates, dashboards, decision materials, and executive communications for site leadership and governance forums.

Translate complex technical, operational, and portfolio information.

Education and Experience

Bachelor's degree in life sciences, chemistry, engineering, pharmaceutical sciences, business, or related discipline required; advanced degree preferred.

Minimum of 10 years of pharmaceutical, biotechnology, or related life sciences experience, with significant experience in program/project management and CMC, manufacturing, process development, or site operations.

Demonstrated experience leading cross-functional, matrixed teams and complex programs with multiple stakeholders, risks, dependencies, and competing priorities.

Experience supporting CMC execution, manufacturing readiness, technology transfer, supply chain planning, or commercial readiness strongly preferred.

Experience building program management capabilities, operating models, governance routines, dashboards, systems, and KPIs preferred.

Prior people management experience preferred.

Skills and Qualifications

Strategic, execution-focused leader able to translate portfolio priorities into actionable plans and measurable outcomes.

Strong understanding of drug development, CMC, manufacturing, supply chain, quality, regulatory, and/or radiopharmaceutical environments.

Proven ability to influence senior leaders and align cross-functional teams without