Director, Oncology Early Translational Biomarkers

SHPE Houston

Waltham (MA)

On-site

USD 190,000 - 316,000

Full time

14 days+

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Job summary

GSK is seeking a Director of Oncology Early Translational Biomarkers to lead biomarker strategy across early oncology programs. You will partner with researchers, clinicians, and CROs to translate preclinical data into clinical plans and inform go/no-go decisions.

The role requires deep oncology biomarker expertise and experience delivering assay development from preclinical to Phase 1. The position involves working with Oncology Research, Clinical Development, Diagnostics, and external

Qualifications

PhD and/or MD with substantial experience in Oncology and immune-oncology.
Minimum 5 years in translational medicine, biomarker science and clinical development.
Expertise in cancer biology across NSCLC/SCLC, GI cancers, and hematologic malignancies.
Experience across modalities: small/large molecules and immune cell engagers.
Hands-on experience with biomarker platforms: flow cytometry, NGS, FISH, PCR, IHC/IF.

Responsibilities

Act as translational medicine lead for early oncology programs; define biomarker strategies.
Identify new science and technologies to enrich biomarker plans and patient selection.
Develop program-specific translational plans and assay strategies.
Provide input on target validation, pharmacology, and MoA across modalities.
Lead biomarker assay selection and validation with internal/ CRO partners.
Integrate preclinical data with clinical plans to inform dose and endpoints.
Represent translational perspectives in program governance and reviews.
Prepare translational updates for protocols and regulatory documents.
Mentor junior scientists and manage external scientific partnerships.